REPLACE: Can Exercise Replace Inhaled Corticosteroid Treatment in Asthma? A RCT

Exclusion Criteria

• •Unable to speak and understand Danish
• •Infection within 4 weeks prior to visit 100\*
• •Asthma exacerbation within 4 weeks prior to visit 100\*
• •Hospitalized for an asthma attack during the last 2 months
• •Treatment with immunotherapy within 5 T½ of the treatment drug prior to visit 100
• •Initiation of allergen immunotherapy within 3 months prior to visit 100 or plan to begin therapy during study period
• •Treatment with peroral prednisolone
• •Respiratory: other chronic pulmonary disease of clinically significance
• •Cardiovascular: Unstable ischemic heart disease, myocardial infarction within the last 12 months, symptomatic heart failure (NYHA III-IV or EF \<40%), symptomatic heart arrhythmia (documented with ECG), uncontrolled hypertension (\>155/100)
• •Pregnancy or breastfeeding or planned pregnancy within the next 12 months
• •Other inflammatory or metabolic diseases with the exception of rhinitis, atopy and well-controlled hypothyroidism treated with or without Eltroxin
• •Vaccination less than 2 weeks prior to any visit
• •Current or former smokers with \> 20 pack years
• •Subjects, who by investigators determination, will not be able to adhere to study protocol
• •* If patients are excluded due to a recent infection or exacerbation they can undergo re-screening after a total of 4 weeks after end of exacerbation treatment/clearing the infection.