Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

Inclusion Criteria

• •1. Provision of signed and dated written informed consent prior to any study-specific procedures.
• •2. Adults aged 18-75, inclusive when signing the informed consent.
• •3. Documented physician-diagnosis of asthma for at least 12 months.
• •4. Treated with medium or high dose ICS in combination with LABA.
• •5. Demonstration of uncontrolled asthma through ACQ-6 score ≥ 1.5 .
• •6. Pre-bronchodilator FEV1 ≥ 40% to ≤ 90% of predicted normal.
• •7. Documented exacerbation history in the last 12 months and biomarker requirements of:
• •1. 2 severe exacerbations OR
• •2. 1 severe exacerbation and:
• •(i) Eosinophils ≥ 150 cells/µl or (ii) FeNo ≥ 25 ppb
• •8. Participants need to demonstrate a ≥70% compliance for Asthma Daily Diary.
• •9. Women of Child Bearing Potential (WOCBP) must have a negative pregnancy test.
• •10. Contraceptive use by males and females should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.