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A Phase II, Open-label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of MPDL3280A (Anti-PD-L1 Antibody) Compared With Docetaxel in Patients With Non-Small Cell Lung Cancer After Platinum Failure
This multicenter, open-label, randomized study will evaluate the efficacy and safety of Atezolizumab compared with docetaxel in participants with advanced or metastatic non-small cell lung cancer after platinum failure. Participants will be randomized to receive either Atezolizumab 1200 milligram (mg) intravenously every 3 weeks or docetaxel 75 milligram per meter square (mg/m\^2) intravenously every 3 weeks. Treatment with Atezolizumab may be continued as long as participants are experiencing clinical benefit as assessed by the investigator, i.e., in the absence of unacceptable toxicity or symptomatic deterioration attributed to disease progression.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Arizona Oncology Associates, PC - HOPE
Tucson, Arizona, United States
Genesis Cancer Center
Hot Springs, Arkansas, United States
Loma Linda University Medical Center
Loma Linda, California, United States
Kaiser Permanente - San Marcos
San Marcos, California, United States
Kaiser Permanente - Vallejo
Vallejo, California, United States
Innovative Clinical Research Institute
Whittier, California, United States
Rocky Mountain Cancer Centers - Colorado Springs (Circle)
Lone Tree, Colorado, United States
Ocala Oncology Center
Ocala, Florida, United States
Georgia Cancer Specialists
Atlanta, Georgia, United States
Ingalls Memorial Hospital
Harvey, Illinois, United States
Start Date
August 6, 2013
Primary Completion Date
November 19, 2015
Completion Date
September 6, 2018
Last Updated
October 2, 2019
287
ACTUAL participants
Docetaxel
DRUG
Atezolizumab
DRUG
Lead Sponsor
Hoffmann-La Roche
NCT06305754
NCT07190248
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07100080