Effect of NeuroAD on the Cognitive Function of Alzheimer Patients

Exclusion Criteria

• •1. CDR 0, 0.5 or 3
• •2. Severe agitation
• •3. Mental retardation
• •4. Patient lacking capacity to consent to study participation
• •5. Unstable medical condition
• •6. Use of benzodiazepines or barbiturates 2 weeks prior to screening
• •7. Pharmacological immunosuppression
• •8. Participation in a clinical trial with any investigational agent within 6 months prior to study enrollment
• •9. History of Epileptic Seizures or Epilepsy
• •10. Contraindication for performing MRI scanning
• •11. Contraindication for receiving TMS treatment according to a TMS questionnaire
• •12. Pregnant women and women who have the ability to become pregnant unless they are on an acceptable method of contraception during the study.
• •13. Patients with depression, bipolar disorder or psychotic disorders or any other neurological or psychiatric condition (whether now or in the past), which the Investigator finds as interfering with the study
• •14. Alcoholism or drug addiction as defined by DSM-IV within last 5 years (addicted more than one year and or in remission less than 3 years) or severe sleep deprivation
• •15. Patients with metal implants in the head, (i.e. cochlear implants, implanted brain stimulators, aneurysm clips) with the exception of metal implants in mouth
• •16. Patients with personal history of either any clinically defined medical disorder (which the investigator finds as interfering with the study) or any clinically defined neurological/psychiatric disorder (other than AD), including (but not limited to): epilepsy, stroke, brain lesions, substance abuse, vitamin B12 deficiency, abnormal thyroid function, cerebrovascular condition, other neurodegenerative disease, head trauma, multiple sclerosis; or personal history of previous neurosurgery or head trauma that resulted in loss of consciousness.
• •17. Patients with any signs or symptoms of increased intracranial pressure, as determined in a neurological exam.
• •18. Cardiac pacemakers
• •19. Implanted medication pumps
• •20. Intracardiac lines
• •21. Significant heart disease
• •22. Currently taking medication that lower the seizure threshold.
• •23. Patients on which TMS Motor Threshold cannot be found.
• •24. Patient underwent TMS treatment in the past.