A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Exclusion Criteria

• •Has a known history of stroke or cerebrovascular disease
• •Has diagnosis of a clinically relevant central nervous system disease other than AD or other condition that negatively impacts cognition or cognitive status chronically
• •Has structural brain disease
• •Has a history of seizures or epilepsy within 5 years before screening
• •Has any other major central nervous system trauma, or infections that affect brain function
• •Has major medical illness or unstable medical condition within 3 months before screening
• •Has a severe, acute, or chronic medical or psychiatric condition or laboratory abnormality
• •Has any immunological disease, which is not adequately controlled, or which requires treatment with biologics and/or immunosuppressants during the study
• •Has a bleeding disorder that is not under adequate control
• •Has a history of malignancy occurring within 5 years of screening
• •Has a risk factor for corrected QT interval (QTc) prolongation
• •Has liver disease
• •Is unwilling or unable to undergo computed tomography (CT), positron emission tomography (PET), or magnetic resonance imaging (MRI) scan
• •Resides in a nursing home or assisted care facility with need for direct continuous medical care and nursing supervision