A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

Exclusion Criteria

• •Has non-AD dementia
• •Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2× upper limit of normal (ULN)
• •Has total bilirubin \>1.5×ULN
• •Has known human immunodeficiency virus infection
• •Has history of hepatitis C virus or current hepatitis B virus infection
• •Has systolic blood pressure \>160 mmHg and/or a diastolic blood pressure \>100 mmHg after 10 minutes of rest at screening
• •Has an estimated glomerular filtration (eGFR) of \<45 mL/min/1.73 m\^2 at screening
• •Has clinically significant ECG abnormalities at screening
• •Has uncontrolled psychiatric disease, including patients deemed by the Investigator to be at significant risk of suicide, major depressive episode, psychosis, confusional state, or violent behavior
• •Has history of bleeding diathesis or coagulopathy due to chronic conditions
• •Has a medical history of brain or spinal disease that would interfere with the IT injection and LP procedures
• •Has history of uncontrolled seizures within the last 6 months prior to Screening