Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM)

Exclusion Criteria

• •Any of the following will exclude a healthy subject from the study:
• •Regular use of vasoactive medication with may interfere with the study procedure, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
• •Symptoms of a clinically relevant illness in the 3 weeks before the first study day
• •Blood donation during the previous 3 weeks
• •Any of the following will exclude a patient with IDDM from the study:
• •Evidence of any relevant retinal or choroidal disease (Glaucoma, age related macula degeneration, cataract, history of central retinal artery obstruction or central retinal vein thrombosis)
• •Ophthalmological surgery (history of photo laser coagulation, including argon laser trabeculoplasty (ALT), trabeculectomy, deep sclerectomy)
• •History of intravitreal injection with anti-proliferative therapy
• •Need for dialysis
• •Non-treated systemic hypertension (SPB\>150, DBP\>95)
• •Evidence of coronary heart disease, cardiomyopathy, stenocardia, congestive heart failure, peripheral occlusive vascular disease, cardiac autonomic neuropathy
• •Symptoms of a clinically relevant illness in the 3 weeks before the first study day
• •Blood donation during the previous 3 weeks