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Open-Label Phase 1b Study of Erlotinib Plus Bevacizumab and IMO-2055 in Patients With Non-Small Cell Lung Cancer Who Have Progressed Following Initial Chemotherapy for Advanced or Metastatic Disease
To evaluate the safety of the proposed Phase II dosage of the investigational drug IMO 2055 when combined with erlotinib and bevacizumab in patients with previously treated advanced NSCLC.
Phase 1b study of escalating doses of weekly subcutaneous IMO-2055 combined with fixed standard dose regimens of oral erlotinib (daily) and IV bevacizumab (every 3 weeks) in patients with previously treated advanced NSCLC.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Cancer Centers of Florida
Ocoee, Florida, United States
Central Indiana Cancer Centers
Indianapolis, Indiana, United States
New York Oncology Hematology P.C.
Albany, New York, United States
Mary Crowley Medical Research Center
Dallas, Texas, United States
Cancer Therapy and Research Center
San Antonio, Texas, United States
Tyler Cancer Center
Tyler, Texas, United States
Virginia Oncology Associates
Norfolk, Virginia, United States
Northwest Cancer Specialists
Vancouver, Washington, United States
Yakima Valley Memorial Hospital/North Shore Cancer Lodge
Yakima, Washington, United States
Start Date
November 1, 2007
Primary Completion Date
October 1, 2010
Completion Date
March 1, 2011
Last Updated
October 22, 2013
36
ACTUAL participants
IMO-2055
DRUG
Lead Sponsor
EMD Serono
NCT06305754
NCT07190248
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07100080