The Use of Rosiglitazone to Treat Asthma

Exclusion Criteria

• •Age 18 or younger
• •FEV1 \<60% predicted value
• •History or presence of significant renal, hepatic,neurologic, cardiovascular, hematologic, cerebrovascular, respiratory, endocrine, gastrointestinal, or collagen vascular disorder that in the Investigator's opinion could interfere with the study or require medical attention that would interfere with the study.
• •History of cancer other than basal cell skin cancer
• •History of hypoglycemia
• •Current smokers, greater than 10 pack year history, or patients quitting less than 1 year prior to screening
• •History within the past year of excessive alcohol intake or drug addiction
• •History of respiratory infection requiring treatment with an antibiotic within 2 week prior to visit 1
• •Chronic intermittent use of inhaled, oral, intra-muscular, topical or intravenous corticosteroids within 4 weeks of visit 1
• •Inability to perform consistent spirometry or nitric oxide exhalation
• •Treatment with an experimental, non-approved drug, or investigational drug within the past 30 days
• •Known hypersensitivity to rosiglitazone
• •History of noncompliance to medical regimens and participants who are considered to be potentially unreliable