Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, Non-Small Cell Lung Cancer, or Mesothelioma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Cytologically or histologically confirmed diagnosis of 1 of the following:
• * Acute myeloid leukemia, meeting the following criteria:
• * Documented Wilms tumor-1 (WT-1)-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease with real-time quantitative reverse transcriptase-polymerase chain reaction (RQ-PCR)
• * Completed induction chemotherapy, achieved clinical remission, and completed postremission therapy OR achieved clinical remission and have no plans for further postremission chemotherapy (≥ 65 years of age)
• * Myelodysplastic syndromes, meeting the following criteria:
• * Documented WT-1-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease by RQ-PCR
• * International Prognostic Scoring System (IPSS) score of ≥ Int-2
• * Not a candidate for cytotoxic chemotherapy
• * Non-small cell lung cancer, meeting the following criteria:
• * Positive tumor staining for WT-1 in \> 10% of cells
• * Stage III or IV disease
• * Completed chemotherapy, surgery, and/or radiotherapy
• * Mesothelioma, meeting the following criteria:
• * Positive tumor staining for WT-1 in \> 10% of cells
• * Unresectable or relapsed disease
• * Chemo-naive or received 1 prior chemotherapy regimen
• * Malignant pleural mesothelioma or peritoneal mesothelioma
• No leptomeningeal disease
• No CNS involvement
• PATIENT CHARACTERISTICS:
• Karnofsky performance status 70-100%
• Absolute neutrophil count ≥ 1,000/mm³
• Platelet count \> 50,000/mm³ (except for myelodysplastic syndromes where parameter is \> 20,000/mm³ and not transfusion dependent)
• Bilirubin ≤ 2.0 mg/dL
• AST and ALT ≤ 2.5 times upper limit of normal
• Creatinine ≤ 2.0 mg/dL
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No active infection requiring systemic antibiotics, antiviral, or antifungal treatments
• No serious unstable medical illness
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• At least 4 weeks since prior chemotherapy or radiotherapy
• No concurrent systemic corticosteroids