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1–20 of 138
Not yet recruiting
Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients
This clinical trial aims to evaluate the clinical efficacy and safety of Deep Cervical Lymphaticovenous Anastomosis (DLVA) in patients aged 50-80 with moderate to severe…
NCT06978946
·
Shanghai, Shanghai Municipality
Completed
A Study to Evaluate Temporary Blood Brain Barrier Disruption in Patients With Parkinson's Disease Dementia
The goal of this prospective, non-randomized, single-arm, feasibility study is to develop data to evaluate the safety and initial efficacy of this treatment (temporary disruption…
NCT03608553
·
Móstoles, Madrid
Completed
Cognitive Dysfunction In Parkinson's
We hypothesize that reductions in gamma activity are a key mechanism underlying cognitive dysfunction in PD and that interventions to increase gamma activity will improve…
NCT02468804
·
Aurora, Colorado
Recruiting
Neuroimaging of Parkinson's
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex.
NCT07024875
·
St Louis, Missouri
Recruiting
Exergaming for Improving Upper Limb Functions in Parkinson's Disease
Parkinson's Disease commonly results in impaired hand dexterity, reducing a patient's ability to perform activities of daily living.
NCT07475741
·
Lahore, Punjab Province
Not yet recruiting
LRRK2 (Leucine-Rich Repeat Kinase 2) Parkinson's Disease Fingerprint
The goal of this interventional monocentric study is to identify molecular and clinical markers of LRRK2-related Parkinson's disease through blood markers analysis and deep…
NCT07681219
Active not recruiting
A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
This is a multicenter, randomized, double-blind, placebo-controlled study that will evaluate the efficacy and safety of intravenous (IV) prasinezumab versus placebo in…
NCT04777331
·
Birmingham, Alabama and 109 others
Not yet recruiting
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep…
NCT06644573
·
Aventura, Florida
Completed
[11C]Donepezil PET For Imaging The Autonomous Nervous System In Parkinsons Disease
AIM: Investigate wether there are differences in the parasympathetic nervous system in Parkinsons patients compared to controls.
NCT02012595
·
Aarhus
Completed
Study of (Mirapex) Pramipexole for the Early Treatment of Parkinsons Disease (PD)
This is a double blind, placebo-controlled clinical trial of 15 months duration designed to examine early Mirapex (pramipexole) treatment vs. delayed Mirapex (pramipexole)…
NCT00321854
·
Brimingham, Alabama and 98 others
Not yet recruiting
Comparing Biomarker-Guided DBS Programming With Standard Clinical Monopolar Programming
The goal of this clinical trial is to learn whether an objective, data-guided approach to programming deep brain stimulation (DBS) can improve motor outcomes in people with…
NCT07369310
·
Barcelona
Active not recruiting
MR-guided Focused Ultrasound Plus GCase
The goal of this study is to establish safety and feasibility of intracerebral delivery of GCase via MRgFUS.
NCT05565443
·
Toronto, Ontario
Completed
Monitoring Anti-Dementia Drugs by Serum Levels
The main objective of the MONANTI study is twofold: Firstly, to determine the serum concentration (SC) the anti-dementia drugs donepezil and memantine in a broadly defined…
NCT04117178
·
Roskilde, Region Sjælland
Recruiting
Transcranial Direct Current Stimulation for Motor Function and Fatigue in PD
The investigators hypothesize that multi-session anodal tDCS (atDCS) of the left primary motor cortex (M1) will induce long-lasting effects in improving motor function and…
NCT06883266
·
Fargo, North Dakota
Completed
Exercise Dosing Trial for Individuals With Parkinson's Disease
This is a prospective, pre-post intervention study to evaluate the effect of a high-intensity, aerobic exercise program on outcomes of cognition, mood, gait, balance…
NCT02676804
·
Charlottesville, Virginia
Completed
Subthalamic Deep Brain Stimulation (DBS) in Parkinson's Disease
The purpose of this study is to examine the brain changes in people with Parkinson's Disease (PD) after they get deep brain stimulation (DBS) surgery, compared with people who do…
NCT02012647
·
Gainesville, Florida
Completed
Pharmacokinetic Study of LY03003 in Patients With Parkinson's Disease
This is a Phase 1, open-label, parallel-group study to evaluate rotigotine pharmacokinetics, safety and tolerability following a single intramuscular dose of one of two different…
NCT03589066
·
Hallandale, Florida and 1 other
Not yet recruiting
Occupation-Based Cognitive Stimulation With and Without Motivational Feedback in Parkinson's Disease
Background: Cognitive impairment and psychological symptoms are highly prevalent in Parkinson's disease (PD) and significantly compromise daily functioning and quality of life.
NCT07630194
Completed
Internet-CBT for Parkinsons Disease
The aim of the study is to investigate if an Internet-based psychological treatment based on principles from Cognitive Behavioral Therapy can increase function and quality of life…
NCT02627885
·
Stockholm
Recruiting
Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease
This study evaluates the use of an oral multi-strain probiotic in the treatment of depression in individuals with Parkinson's Disease.
NCT05568498
·
Vancouver, British Columbia
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