Study of UB-312 in Healthy Participants and Parkinson's Disease Patients

Exclusion Criteria

• •Clinically significant abnormalities, as judged by the investigator
• •History of medical, neurological or psychiatric conditions which in the opinion of the investigator may compromise participant's safety or scientific value of the study
• •Acute or chronic infection as judged by the investigator, for positive human immunodeficiency virus (HIV), hepatitis C virus (HCV) or hepatitis B virus (HBV)
• •History or evidence of an autoimmune disorder
• •History of anergy.
• •Participated/participating in any clinical trial with monoclonal antibodies or vaccines directed at aSyn
• •For Part B only:
• •Other known or suspected cause of Parkinsonism other than idiopathic PD
• •History or evidence at Screening of PD-related freezing episodes, falls, or orthostatic hypotension
• •Dopamine transporter single-photon emission computerized tomography scan (DaTscan) inconsistent with dopamine transporter deficit.
• •Clinically significant neurological disease other than PD