Clinical Trials in Tennessee

Showing 17701-17720 of 20,239 trials

Brain Manganese Deposition in High Risk Neonates

NCT00392977

Excessive exposure to manganese (Mn) results in Mn deposition in the brain causing adverse neurological effects. Sick infants requiring parenteral nutrition (PN) may be at increased risk of Mn neurotoxicity because neonatal PN solutions contain high concentrations of Mn. This proposal will investigate brain deposition of Mn, a paramagnetic element, by magnetic resonance (MR) imaging in preterm and term neonates receiving Mn-supplemented PN and gestational age-matched control infants. The goals of this project are to identify neonatal populations that are at increased risk of excessive brain Mn deposition based on their gestational age, iron status, hepatic function and dietary Mn intake, and to make evidence-based recommendations for appropriate Mn supplementation and monitoring of infants receiving PN.

Necrotizing EnterocolitisDigestive System AbnormalitiesCholestasis

Vanderbilt University43 participantsStarted Aug 2006

Nashville, Tennessee, United States

COMPLETEDPhase 329 miles

Eflornithine in Treating Patients With Bladder Cancer

NCT00003814

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if eflornithine is more effective than no further therapy in treating bladder cancer. PURPOSE: Randomized phase III trial to determine the effectiveness of eflornithine in treating patients who have newly diagnosed or recurrent bladder cancer.

Bladder Cancer

National Cancer Institute (NCI)450 participantsStarted Feb 1999

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Anaheim, California, United States +58 more locations

Brain Manganese Deposition in High Risk Neonates

Eflornithine in Treating Patients With Bladder Cancer

Find Trials by Condition in Tennessee

Situational Problem Solving in Adolescents With Type 2 Diabetes: Enhancing a Randomized Controlled Trial (RCT)

Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder

Timing of Target Enteral Feeding in the Mechanically Ventilated Patient

Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)

The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications

Marimastat in Treating Patients With Stage III Non-small Cell Lung Cancer

Efficacy and Safety of Vortioxetine (Lu AA21004) in the Treatment of Patients With Major Depressive Disorder

Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma

Photodynamic Therapy in Treating Patients With Recurrent, Refractory, or Second Primary Head and Neck Cancer That Cannot Be Treated With Surgery or Radiation Therapy

GS-5885, GS-9451, Tegobuvir and Ribovirin in Treatment-Experienced Subjects With Chronic Genotype 1a Or 1b Hepatitis C Virus (HCV) Infection

Effective Communication for Preventing and Responding to Oncology Adverse Events

Vaccine Therapy in Treating Patients With Malignant Melanoma

REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent

GM-CSF With or Without Vaccine Therapy After Combination Chemotherapy and Rituximab as First-Line Therapy in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma

Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)

Bortezomib in Treating Patients With Advanced Cancer and Liver Dysfunction

A Phase I/II Study of Dasatinib and Dacarbazine

A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)