A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)

Exclusion Criteria

• •History of pre-diabetes or diabetes
• •Previous or current treatment with any anti-diabetic drugs
• •Serum creatinine \> 2.0 mg/dL in males and \> 1.8 mg/dL in females
• •Active smokers defined as having smoked their last cigarette, pipe, and/or cigar without the previous 6 months
• •Previous exposure to any inhaled insulin product or investigational medicines/devices within the previous 30 days prior to entry or participation
• •Clinically significant major organ disease
• •Female subjects of childbearing potential not practicing adequate birth control
• •Subjects with COPD: Significant improvement in pre-to post-bronchodilator spirometry (defined as an increase of 12% AND 200 mL in either FVC or FEV1);
• •Any clinically important pulmonary disease except mild or moderate COPD
• •Subjects without COPD: Any important pulmonary disease confirmed by pulmonary function testing and/or radiologic findings