Clinical Trials in Tennessee

Showing 5421-5440 of 20,239 trials

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

NCT05759949

This is a Phase 1, first-in-human, open-label study designed to evaluate the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of RLY-5836 in advanced solid tumors in participants harboring a PIK3CA mutation in blood and/or tumor per local assessment. The study consists of 2 parts, a dose escalation (Part 1) and a dose expansion (Part 2).

PIK3CA MutationSolid Tumor, AdultHER2-negative Breast Cancer+5 more

Relay Therapeutics, Inc.41 participantsStarted Mar 2023

Orlando, Florida, United States • Indianapolis, Indiana, United States • Boston, Massachusetts, United States +4 more locations

RECRUITINGPhase 429 miles

VZV in the Enteric Nervous System: Pathogenesis and Consequences

NCT05550194

Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder ("enteric shingles"). The Investigators recently found that a chronic active VZV infection, a form of enteric shingles, is associated with achalasia, a severe disease in which the passage of food from esophagus to stomach is impaired. We now propose to eradicate VZV to determine whether its association with achalasia is causal, to identify the genetic basis behind VZV reactivation in the esophagus, and the relationship of mast cells to enteric shingles and abdominal pain.

Achalasia

Vanderbilt University Medical Center40 participantsStarted Mar 2023

Nashville, Tennessee, United States

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

VZV in the Enteric Nervous System: Pathogenesis and Consequences

Find Trials by Condition in Tennessee

VAY736 in Combination With Ibrutinib in Patients With CLL on Ibrutinib

Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer

A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer

Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney Disease

Study of TH-302 or Placebo in Combination With Pemetrexed in Patients With Non-squamous Non-small Cell Lung Cancer

Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis

Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

Safety, Tolerability and Pharmacokinetics Study of KPG-818 in Hematological Malignancies Subjects

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease (STAAR)

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension

Natural Versus Programmed Frozen Embryo Transfer (NatPro)

Functional and Non-Functional CSF Shunt Flow Measured With a Second-Generation Wireless Thermal Device

Measurements of CSF Shunts and Off-Shunt Locations With Wireless Thermal Anisotropy Measurement Devices

Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

Cognition and Imaging With Tigertriever

A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC