Clinical Trials in Pittsburgh

Showing 13501-13520 of 18,076 trials

Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer

NCT01951690

This is a Phase II, open-label, multicenter, multi cohort, study of VS-6063 (defactinib), a focal adhesion kinase inhibitor, in patients with KRAS mutant non-small cell lung cancer (NSCLC). NSCLC with a KRAS mutation is required for study entry and subjects will be enrolled into 1 of 4 cohorts based on the status of their INK4a/Arf and p53 mutations. The purpose of this study is to demonstrate if VS-6063 (defactinib) improves PFS within each cohort. The safety and tolerability of VS-6063, tumor response rate, progression free survival and overall survival will also be assessed. The pharmacodynamic effects of VS-6063 (defactinib) will be examined in a tumor biopsy and a blood sample.

Non Small Cell Lung CancerLung Cancer

Verastem, Inc.55 participantsStarted Sep 2013

Denver, Colorado, United States • Atlanta, Georgia, United States • Baltimore, Maryland, United States +6 more locations

COMPLETEDPhase 3< 1 mile

Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM)

NCT00916409

The study is a prospective, randomly controlled pivotal trial, designed to test the efficacy and safety of a medical device, the NovoTTF-100A, as an adjuvant to the best standard of care in the treatment of newly diagnosed GBM patients. The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays.

Glioblastoma Multiforme

NovoCure Ltd.700 participantsStarted Jun 2009

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Duarte, California, United States +86 more locations

Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer

Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM)

Find Trials by Condition in Pittsburgh

A Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV Melanoma

A Study of MEDI-575 in Subjects With Recurrent Glioblastoma Multiforme

Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS

S0927:Omega3-Fatty Acid Supp in Treating Muscle&Bone Pain&Stiffness in Pts W/Stg I,II,III Brst Canc Rec'v Hormone Thpy

Bipolar Disorder Study for Men and Women

Progel Vascular Sealant

Efficacy and Safety of 20 mg Sumatriptan Powder Delivered Intranasally With the Bi-directional Device Compared With 100 mg Sumatriptan Tablets in Adults With Acute Migraine With or Without Aura

A Trial Comparing Efficacy and Safety of Insulin Degludec and Insulin Glargine in Insulin naïve Subjects With Type 2 Diabetes

Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries

Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms

Depression in Alzheimer's Disease-2

A Study to Assess the Effect and Safety of AZD6765 in Patients With Major Depressive Disorder

Healing With Venlafaxine After Injury (HELP)

3-year Follow-up Study in Patients Previously Treated With TMC435-Containing Regimen for the Treatment of Hepatitis C Virus Infection

Safety, Tolerability and Efficacy of Etelcalcetide in Hemodialysis Patients With Secondary Hyperparathyroidism

TruSkin®: Study for the Treatment of Chronic Diabetic Foot Ulcers

Prolonging Remission in Depressed Elderly (PRIDE)

Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG)