Pegylated Liposomal Doxorubicin Hydrochloride, Carboplatin, Veliparib, and Bevacizumab in Treating Patients With Recurrent Ovarian Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer

Exclusion Criteria

• •Patients who have received more than one previous regimen of chemotherapy (maintenance is not considered a second regimen)
• •Patients who have received prior ABT-888 or any other poly-adenosine diphosphate (ADP)--ribose polymerase (PARP) inhibitor
• •Patients who have received prior PLD
• •History of allergic reactions attributed to compounds of similar chemical or biologic composition to ABT-888 or other agents used in this study
• •Patients with other invasive malignancies, with the exception of non-melanoma skin cancer and other specific malignancies are excluded if there is any evidence of other malignancy being present within the last three years; patients are also excluded if their previous cancer treatment contraindicates this protocol therapy
• •Patients who have received prior radiotherapy to any portion of the abdominal cavity or pelvis are excluded; prior radiation for localized cancer of the breast, head and neck, or skin is permitted, provided that it was completed more than three years prior to registration, and the patient remains free of recurrent or metastatic disease
• •Patients who have received prior chemotherapy for any abdominal or pelvic tumor (other than ovarian, fallopian tube and primary peritoneal) are excluded; patients may have received prior adjuvant chemotherapy for localized breast cancer, provided that it was completed more than three years prior to registration, and that the patient remains free of recurrent or metastatic disease
• •Patients with synchronous primary endometrial cancer or a history of endometrial cancer, unless all of the following conditions are met:
• •* Stage not greater than IB
• •* No more than superficial myometrial invasion
• •* No vascular or lymphatic invasion
• •* No poorly differentiated subtypes, including papillary serous, clear cell, or other International Federation of Gynecology and Obstetrics (FIGO) grade 3 lesions
• •Patients with known chronic or active hepatitis or ongoing or active infection that requires parenteral antibiotics
• •Patients with concurrent severe medical problems unrelated to the malignancy that would significantly limit full compliance with the study or expose the patient to extreme risk or decreased life expectancy
• •Patients with seizures or a history of seizures are ineligible
• •Patients with history or evidence upon physical examination of central nervous system (CNS) disease, including primary brain tumor, any CNS metastases, or history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within six months of the first date of treatment on this study; patients with CNS metastases must be stable for \> 3 months after treatment and off steroid treatment prior to study enrollment
• •Patients who cannot swallow pills
• •ADDITIONAL CRITERIA FOR PATIENTS BEING TREATED ON BEVACIZUMAB COHORT:
• •History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab
• •Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with bevacizumab
• •Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
• •Urine protein should be screened by urine analysis; if protein is 2 + or higher, 24-hour urine protein should be obtained and the level should be \< 1000 mg for patient enrollment
• •Serious non-healing wound, ulcer, or bone fracture
• •History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months to day 1
• •Invasive procedures defined as follows:
• •* Major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to day 1 therapy
• •* Anticipation of need for major surgical procedures during the course of the study
• •* Core biopsy within 7 days prior to day 1 (D1) therapy
• •Significant vascular disease (e.g., aortic aneurysm, requiring surgical repair or recent peripheral arterial thrombosis) within 6 months prior to day 1
• •Known CNS disease except for treated brain metastases; treated brain metastases are defined as having no ongoing requirement for steroids and no evidence of progression or hemorrhage after treatment for at least 3 months, as ascertained by clinical examination and brain imaging (magnetic resonance imaging \[MRI\] or computed tomography \[CT\]); (stable dose of anticonvulsants are allowed); treatment for brain metastases may include whole brain radiotherapy (WBRT), radiosurgery (RS; Gamma Knife, LINAC, or equivalent) or a combination as deemed appropriate by the treating physician; patients with CNS metastases treated by neurosurgical resection or brain biopsy performed within 3 months prior to Day 1 will be excluded
• •Patients with clinically significant cardiovascular disease are excluded
• •* Inadequately controlled hypertension (HTN) (systolic blood pressure \[SBP\] \> 160 mm Hg and/or diastolic blood pressure \[DBP\] \> 90 mm Hg despite antihypertensive medication)
• •* History of cerebrovascular accident (CVA) within 6 months
• •* History of myocardial infraction or unstable angina within 6 months
• •* New York Heart Association grade II or greater congestive heart failure
• •* Serious and inadequately controlled cardiac arrhythmia
• •* Significant vascular disease (e.g. aortic aneurysm, history of aortic dissection)
• •* Clinically significant peripheral vascular disease
• •Evidence of bleeding diathesis or coagulopathy
• •Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies