Clinical Trials in Pittsburgh

Showing 13361-13380 of 18,076 trials

Rediscovering Hydroxychloroquine as a Novel Insulin Sensitizer

NCT02124681

Current options to treat insulin resistance in diabetes are fairly limited. For this reason, novel treatments would represent a major progress. The generic drug hydroxychloroquine (HCQ) has poorly understood effects on blood sugar metabolism. In this study, the investigators will examine the mechanisms by which this drug affects glucose metabolism and which cells are affected. Findings emanating from this project will help establish whether HCQ may be a viable treatment for disorders of glucose metabolism.

Insulin Resistance

University of Pittsburgh34 participantsStarted Apr 2014

Pittsburgh, Pennsylvania, United States

COMPLETEDNA< 1 mile

Covered Metallic Stents for First-Line Treatment of Benign Bile Duct Strictures

NCT01221311

The current standard of care for benign bile duct strictures involves placement of multiple plastic stents under endoscopic and fluoroscopic guidance to progressively dilate or stretch it open. This approach necessitates multiple procedures which may extend over one year before the stricture is adequately dilated. The investigators propose a study comparing the standard approach of plastic stenting with the use of newer, fully coated metallic stents which are self-expandable, thereby permitting successful dilation of benign bile duct strictures with fewer procedures.

Common Bile Duct Stricture

Medical University of South Carolina112 participantsStarted Jan 2011

Chicago, Illinois, United States • Indianapolis, Indiana, United States • Ann Arbor, Michigan, United States +5 more locations

Rediscovering Hydroxychloroquine as a Novel Insulin Sensitizer

Covered Metallic Stents for First-Line Treatment of Benign Bile Duct Strictures

Find Trials by Condition in Pittsburgh

Donors After Cardiac Death: Validating Identification Criteria

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time

A Phase II, Repeat Dose, Proof of Mechanism Study of Losmapimod to Reduce Proteinuria in Patients With Focal Segmental Glomerulosclerosis (FSGS)

Study Comparing TVT With TVT-SECUR for the Treatment of Stress Urinary Incontinence

REal World EVidence for TrEAtment of HyperkaLemia in Emergency Department: Multicenter, Prospective, Observational Study

Bisphosphonate Treatment of Osteogenesis Imperfecta

A Phase 1b Study to Assess the Safety and Anti-inflammatory Effects of Two Different Doses of SRT2104 in Patients With Ulcerative Colitis

Efficacy of Prednisone In the Treatment of Ocular Myasthenia

Monitoring Disease Activity Using Video Capsule Endoscopy (VCE) in Crohn's Disease (CD) Subjects

Dose Ranging of GSK2336805 in Combination Therapy

A Three-part Study of Eltrombopag in Thrombocytopenic Subjects With Myelodysplastic Syndromes or Acute Myeloid Leukemia

A 2-Part Trial in Subjects With Type 2 Diabetes and in Healthy Subjects to Evaluate GSK1614235, a New Glucose Lowering Drug to Treat Type 2 Diabetes

Rollover Protocol Continued Access to Emtricitabine/Tenofovir Disoproxil Fumarate for Adults in United States

Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate vs. Intravenous to Oral 10-Day Linezolid in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

A Feasibility Study of Advance Plasma Therapy001 Plasma/Nitric Oxide Therapy for the Treatment of Diabetic Foot Ulcers

A Long Term Safety Study of Mavrilimumab in Adult Subjects With Rheumatoid Arthritis

BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis