Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2

Exclusion Criteria

• •Subjects will be excluded that have: mTBI
• •1. Loss of consciousness (LOC) ≥5 minutes;
• •2. Posttraumatic amnesia lasting ≥24 hr following mTBI;
• •3. Current or prior (within past 10 years) moderate to severe TBI
• •4. Diagnosis of mTBI within the past 6 months;
• •5. Epilepsy with recurring seizures in past 10 years;
• •6. Drug abuse (except marijuana) in past 10 years based on DAST-10 screening;
• •7. Alcohol abuse based on AUDIT-C screening;
• •8. Current primary Axis I or II psychiatric disorders, except for disorders classified as minor and not expected to impact study conduct or integrity (as detailed in Appendix C - Screening Axis I/II Disorders):
• •9. History of brain mass, neurosurgery, stroke, white matter disease, and/or dementia;
• •10. Known cognitive dysfunction or structural brain disease/malformation;
• •11. Structural brain injury on prior neuroimaging findings;
• •12. Been prescribed antipsychotic/antiepileptic medications;
• •13. Unable (such as due to urgent medical care needs) or unwilling to complete study procedures accurately or have any conflict of interest that could affect study results, in the opinion of the investigator;
• •14. Contraindications to MRI scanning, including:
• •* Current or suspected pregnancy, per site practice;
• •* Other conditions that may constitute a hazard to the subject during study participation, per investigator;
• •* Inability to comply with any part of the site's MR safety policy.
• •Subjects will be excluded that have:- non-TBI (controls)
• •1. Diagnosis of mTBI within the past 6 months;
• •2. Prior (within past 10 years) moderate to severe TBI (GCS \<13);
• •3. Epilepsy with recurring seizures in past 10 years;
• •4. Drug abuse (except marijuana) in past 10 years based on DAST-10 screening;
• •5. Alcohol abuse based on AUDIT-C screening;
• •6. Current primary Axis I or II psychiatric disorders, except for disorders classified as minor and not expected to impact study conduct or integrity (as detailed in Appendix C - Screening Axis I/II Disorders):
• •7. History of brain mass, neurosurgery, stroke, white matter disease, and/or dementia;
• •8. Known cognitive dysfunction or structural brain disease/malformation;
• •9. Structural brain injury on prior neuroimaging findings;
• •10. Been prescribed antipsychotic/antiepileptic medications;
• •11. Unable (such as due to urgent medical care needs) or unwilling to complete study procedures accurately or have any conflict of interest that could affect study results, in the opinion of the investigator;