Clinical Trials in Pittsburgh

Showing 11181-11200 of 17,577 trials

Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas

NCT00795457

This is a pilot vaccine study in adults with either WHO grade II astrocytoma, oligoastrocytoma or oligodendroglioma. The purpose of this study is test the safety and efficacy of an experimental tumor vaccine made from peptides and Montanide ISA-51 in combination with the study drug Poly-ICLC. Poly-ICLC, manufactured by Oncovir, Inc., has already been received and generally well tolerated by subjects in earlier studies and has been shown to decrease the size of brain tumors in some cases. The immunological and safety data will be used to decide whether a larger study of clinical efficacy is warranted in each of two patient cohorts.

AstrocytomaOligo-AstrocytomaGlioma

Ian F. Pollack, M.D.13 participantsStarted Jan 2009

Winston-Salem, North Carolina, United States • Pittsburgh, Pennsylvania, United States

COMPLETED< 1 mile

Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children

NCT02182986

Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. However, the same immunosuppressive medications that are required to prevent the child's immune system from attacking and rejecting the transplanted organ can predispose these individuals to developing a very serious cancer that is linked to Epstein-Barr virus (EBV).

Heart TransplantSmall Intestine TransplantKidney Transplant+3 more

National Institute of Allergy and Infectious Diseases (NIAID)944 participantsStarted Aug 2014

Los Angeles, California, United States • Stanford, California, United States • Washington D.C., District of Columbia, United States +4 more locations

Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas

Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children

Find Trials by Condition in Pittsburgh

A Study of Venetoclax Plus Lenalidomide and Dexamethasone for the Treatment of Newly Diagnosed t(11;14)-Positive Multiple Myeloma in Subjects Who Are Ineligible for High-Dose Therapy

Efficacy and Safety Study of PDT Using Photofrin in Unresectable Advanced Perihilar Cholangiocarcinoma (OPUS)

An Extension Study to Evaluate the Long-Term Safety and Tolerability of Ubrogepant in the Treatment of Migraine

Expanded Access Program to Provide Treatment With Pitolisant to Adult Patients in the U.S. With Excessive Daytime Sleepiness Associated With Narcolepsy With or Without Cataplexy

Dendritic Cell Vaccines + Dasatinib for Metastatic Melanoma

A Safety Extension Study to Evaluate the Safety and Tolerability of Benralizumab (MEDI-563) in Asthmatic Adults and Adolescents on Inhaled Corticosteroid Plus LABA

Positive Imaging Study for Distant Metastases in Patients With Castration-Resistant Prostate Cancer

Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder

The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity

A Study to Evaluate the Effect of Dapagliflozin With and Without Saxagliptin on Albuminuria, and to Investigate the Effect of Dapagliflozin and Saxagliptin on HbA1c in Patients With Type 2 Diabetes and CKD

A Study of ERY974 in Patient With Advanced Solid Tumors

An Effectiveness and Safety Study of Inhaled JNJ 49095397 (RV568) in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity

Dynamic Hyperinflation and Tiotropium

Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA

Pivotal Study in VAP Suspected or Confirmed to be Due to Pseudomonas Aeruginosa

A Phase IIb Study for ALX-0061 Monotherapy in Subjects With Rheumatoid Arthritis

Glasdegib Renal Impairment Study