rVWF IN PROPHYLAXIS

Exclusion Criteria

• •1. The participant has been diagnosed with Type 2N Von Willebrand disease (VWD), pseudo VWD, or another hereditary or acquired coagulation disorder other than VWD (eg qualitative and quantitative platelet disorders or prothrombin time \[PT\]/international normalized ratio \[INR\] greater than \[\>\]1.4).
• •2. The participant is currently receiving prophylactic treatment with more than 5 infusions per week.
• •3. The participant is currently receiving prophylactic treatment with a weekly dose exceeding 240 IU/kg.
• •4. The participant has a history or presence of a VWF inhibitor at screening.
• •5. The participant has a history or presence of a Factor VIII (FVIII) inhibitor with a titer ≥0.4 Bethesda units (BU) (by Nijmegen modified Bethesda assay) or \> or = 0.6 Bethesda Unit (BU) (by Bethesda assay).
• •6. The participant has a known hypersensitivity to any of the components of the study drugs, such as to mouse or hamster proteins.
• •7. The participant has a medical history of immunological disorders, excluding seasonal allergic rhinitis/conjunctivitis, mild asthma, food allergies or animal allergies.
• •8. The participant has a medical history of a thromboembolic event.
• •9. The participant is human immunodeficiency virus (HIV) positive with an absolute Helper T cell (CD4) count \<200/ cubic millimeter (mm\^3).
• •10. The participant has been diagnosed with significant liver disease per investigator's medical assessment of the participant's current condition or medical history or as evidenced by any of the following: serum alanine aminotransferase (ALT) greater than 5 times the upper limit of normal; hypoalbuminemia; portal vein hypertension (e.g., presence of otherwise unexplained splenomegaly, history of esophageal varices).
• •11. The participant has been diagnosed with renal disease, with a serum creatinine (CR) level \> or = 2.5 milligram per deciliter (mg/dL).
• •12. The participant has a platelet count \<100,000/ milliliter (mL) at screening.
• •13. The participant has been treated with an immunomodulatory drug, excluding topical treatment (e.g., ointments, nasal sprays), within 30 days prior to signing the informed consent.
• •14. The participant is pregnant or lactating at the time of enrollment.
• •15. Patient has cervical or uterine conditions causing menorrhagia or metrorrhagia (including infection, dysplasia).
• •16. The participant has participated in another clinical study involving another Investigational product (IP) or investigational device within 30 days prior to enrollment or is scheduled to participate in another clinical study involving an IP or investigational device during the course of this study.
• •17. The participant has a progressive fatal disease and/or life expectancy of less than 15 months.
• •18. The participant is scheduled for a surgical intervention.
• •19. The participant is identified by the investigator as being unable or unwilling to cooperate with study procedures.
• •20. The participant has a mental condition rendering him/her unable to understand the nature, scope and possible consequences of the study and/or evidence of an uncooperative attitude.
• •21. The participant is in prison or compulsory detention by regulatory and/or juridical order.
• •22. The participant is member of the study team or in a dependent relationship with one of the study team members which includes close relatives (i.e., children, partner/spouse, siblings and parents) as well as employees.