Clinical Trials in Pittsburgh

Showing 10901-10920 of 16,007 trials

Oral Nitrite for Older Heart Failure Patients

NCT02457260

Studies have demonstrated nitrite therapy increases adenosine triphosphate (ATP) synthesis in skeletal muscle mitochondria concomitant with reduced whole-body oxygen cost during steady state exercise. Our own work has demonstrated safety and efficacy of an FDA investigational new drug (IND) approved sodium nitrite (10 milligram \[mg\]) capsule, and its utility to upregulate the sirtuin 3 adenosine monophosphate protein kinase (SIRT3-AMP) pathway of skeletal muscle of younger heart failure (HF) patients. It now seems exceptionally logical and opportune to apply these insights to older HF patients and to delineate mechanisms of disease and aging that respond to nitrite therapy.

Heart Failure

Gladwin, Mark, MD21 participantsStarted Jan 2016

Pittsburgh, Pennsylvania, United States

TERMINATED< 1 mile

Natural History Study to Characterise the Course of Disease Progression in Participants With Mucopolysaccharidosis Type IIIB

NCT02293408

The objectives of this study are to describe the clinical and biochemical characteristics and course of disease progression in participants with Mucopolysaccharidosis type IIIB (MPS IIIB)

MPS IIIB (Sanfilippo B Syndrome)

Alexion Pharmaceuticals, Inc.30 participantsStarted Sep 2014

Minneapolis, Minnesota, United States • Pittsburgh, Pennsylvania, United States • Porto Alegre, Brazil +4 more locations

COMPLETEDPhase 3< 1 mile

Cognition in the Study of Tamoxifen and Raloxifene

NCT00687102

The purpose of this study is to assess the effects of tamoxifen and raloxifene on cognitive aging in selected cognitively-healthy women.

CognitionAging

Wake Forest University1,498 participantsStarted Oct 2001

Phoenix, Arizona, United States • Tucson, Arizona, United States • Camp Pendleton, California, United States +131 more locations

Oral Nitrite for Older Heart Failure Patients

Natural History Study to Characterise the Course of Disease Progression in Participants With Mucopolysaccharidosis Type IIIB

Cognition in the Study of Tamoxifen and Raloxifene

Find Trials by Condition in Pittsburgh

Efficacy and Safety of Toujeo® Versus Tresiba® in Insulin-Naive Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Oral Antihyperglycemic Drug(s) ± GLP-1 Receptor Agonist

Immunogenicity, Safety and Reactogenicity Study of GlaxoSmithKline (GSK) Biologicals' Hib-MenCY-TT (MenHibrix®) Vaccine Compared to Merck & Co, Inc. PedvaxHIB Vaccine in Healthy Infants and Toddlers 12 to 15 Months of Age

Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

A Phase 2 Multicenter Randomized Clinical Trial of CNTF for MacTel

Study Evaluating HKI-272 in Tumors

Effect of Intravenous (IV) Vedolizumab on Mucosal Healing in Crohn's Disease

Tivantinib in Treating Patients With Metastatic Prostate Cancer

Surefire Precision Infusion System Registry

Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy

Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors

Hsp90 Inhibitor STA-9090 in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy

ILX-295501 in Treating Patients With Stage III or Stage IV Ovarian Cancer That Has Not Responded to Previous Treatment

A Phase Ib/II Study of the Combination of BYL719 Plus AMG 479 in Adult Patients With Selected Solid Tumors

Predicting Caries Risk in Underserved Toddlers in Primary Healthcare Settings

Pomaglumetad Effects on Glutamate Biomarkers

Investigating Train the Trainer Delivery of Mindfulness-based Training

Open Label Extension Study With Gefitinib (IRESSA™) for Completing Trial Patients Who May Benefit From Further Treatment