A Double-Blind Placebo-Controlled Trial of the Safety and Immunogenicity of a Seven Valent Pneumococcal Conjugate Vaccine in Presumed HIV-Infected Infants

Exclusion Criteria

• •Co-existing Condition:
• •Patients with the following symptoms or conditions are excluded:
• •Enrollment in HIV vaccine trials.
• •Major congenital anomalies that are incapacitating, result in immunologic abnormalities, or require major surgical procedures.
• •Congenital immunoglobulin deficiency, SS or SC hemoglobinopathy, or asplenia.
• •Hypogammaglobulinemia.
• •Concurrent Medication:
• •Excluded:
• •Prophylactic antipyretics.
• •Patients with the following prior conditions are excluded:
• •Acute moderate to severe intercurrent illness or fever within 72 hours prior to study entry.
• •Prior Medication:
• •Excluded:
• •Any prior pneumococcal vaccine.
• •Measles vaccine within 1 month prior to study vaccination.
• •Any other routine vaccine within 1 week prior to study vaccination.
• •Any immunosuppressant agent, including prednisone, for more than 6 weeks.
• •Prior Treatment:
• •Excluded:
• •Blood products within 56 days prior to study vaccination.