Clinical Trials in Pittsburgh

Showing 8741-8760 of 16,007 trials

Safety and Tolerability of SYNB1618 in Healthy Adult Volunteers and Adult Subjects With Phenylketonuria

NCT03516487

This Phase 1/2a, first-in-human, oral single and multiple dose-escalation, randomized, double-blinded, placebo-controlled study is evaluating SYNB1618 in healthy volunteers (HV) and subjects diagnosed with phenylketonuria (PKU), a rare inherited metabolic disorder that occurs in people who are missing an enzyme that the body needs to use phenylalanine (Phe). Eligible subjects receive investigational product (IP) in the clinic and undergo safety monitoring, evaluations, and subsequent follow-up after IP administration.

PhenylketonuriaHealthy

Synlogic70 participantsStarted Apr 2018

Boston, Massachusetts, United States • Pittsburgh, Pennsylvania, United States • Nashville, Tennessee, United States +1 more locations

COMPLETED< 1 mile

St. Jude Medical Product Longevity and Performance (SCORE) Registry

NCT01754064

SCORE is an active, prospective, non-randomized, multi-center outcome-oriented registry of patients implanted with St Jude Medical (SJM) market-released cardiac rhythm management (CRM) products. This registry will be conducted in the United States (US). The primary purpose of the registry is to evaluate and publish acute and long-term performance of market-released SJM CRM products by analyzing product survival probabilities. Product status and any related adverse events will be collected to measure survival probabilities.

BradycardiaTachycardiaHeart Disease

Abbott Medical Devices10,957 participantsStarted Nov 2007

Huntsville, Alabama, United States • Mobile, Alabama, United States • Anchorage, Alaska, United States +77 more locations

Safety and Tolerability of SYNB1618 in Healthy Adult Volunteers and Adult Subjects With Phenylketonuria

St. Jude Medical Product Longevity and Performance (SCORE) Registry

Find Trials by Condition in Pittsburgh

An Open-Label Extension Trial of UT-15C Sustained-release (SR) in Subjects With Pulmonary Arterial Hypertension

A Long Term Study of the Safety of Tanezumab When Administered By Subcutaneous Injections

Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy

Lead Registry for Optim Leads

Extension Study Of Tanezumab In Osteoarthritis

Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin

A Study Evaluating the Efficacy and Safety of ST-0529 in Subjects With Moderately to Severely Active Ulcerative Colitis

A Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab in Participants With Solid Tumors

Maribavir for Prevention of CMV After Stem Cell Transplants

Safety and Efficacy of ALD518 for Reducing Oral Mucositis in Head and Neck Cancer Subjects

Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis

A Study to Test the Safety, Tolerability, and Pharmacokinetics of UCB0599 in Healthy Study Participants and Patients With Parkinson's Disease (PD)

Multiple Ascending Doses of AMG 139 in Healthy and Crohn's Disease Subjects

Bacterial Contamination: Iodine vs Saline Irrigation in Pediatric Spine Surgery

Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing (RESCUE1)

Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfecta

FLT-PET/CT vs FDG-PET/CT for Therapy Monitoring of Diffuse Large B-cell Lymphoma

Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems