Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Rhythm Pharmaceuticals, Inc.
Age
6–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Participants with the following genotypes and/or clinical assessment:
1. POMC/PCSK1/LEPR heterozygous - not currently enrolling new participants
2. POMC/PCSK1/LEPR compound heterozygous (two different mutations in gene) or homozygous deficiency obesity
3. POMC/PCSK1/LEPR composite heterozygous (two or more mutations in two or more genes) deficiency obesity
4. SMS
5. SH2B1 deficiency obesity
6. Chromosomal rearrangement of the 16p11.2 locus causing obesity
7. Carboxypeptidase E (CPE) compound heterozygous or homozygous deficiency obesity
8. Leptin deficiency obesity with loss of response to metreleptin
9. SRC1 deficiency obesity
10. MC4R deficiency obesity
2. Age 6 years and above
3. Obese, defined as Body Mass Index (BMI) ≥ 30 kilogram per meter square (kg/m\^2) for participants ≥16 years of age or BMI≥ 95th percentile for age and gender for participants 6 up to 16 years of age.
4. Participant and/or parent or guardian is able to understand and comply with the requirements of the study and is able to understand and sign the written informed consent/assent
5. Female participants of childbearing potential must be confirmed non-pregnant, and agree to use contraception as outlined in the protocol.
6. Male participants with female partners of childbearing potential must agree to a double barrier method if they become sexually active during the study. Male participants must not donate sperm during and for 90 days following their participation in the study.
You may not be if
1. Recent intensive (within 2 months) diet and/or exercise regimen with or without the use of weight loss agents that has resulted in \> 2% weight loss.
2. Use of any medication that is approved to treat obesity within three months of first dose of study drug (e.g., orlistat, lorcaserin, phentermine-topiramate, naltrexone-bupropion).
3. Gastric bypass surgery within the previous six months or any prior gastric bypass surgery resulting in \>10% weight loss durably maintained
4. Diagnosis of schizophrenia, bipolar disorder, personality disorder, major depressive disorder, or other psychiatric disorder(s)
5. Suicidal ideation, attempt or behavior
6. Clinically significant pulmonary, cardiac, or oncologic disease
