Clinical Trials in Pittsburgh

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A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma

NCT05358379

This is a 2-part, phase 1/2, open-label, multicenter study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, pharmacogenomics, and efficacy of CYC140 administered orally daily. This study consists of Phase 1 and Phase 2 components in subjects with advanced solid tumors and lymphoma who have progressed despite having standard therapy or for which no standard therapy exists.

Solid Tumor, Adult Lymphoma

Cyclacel Pharmaceuticals, Inc.330 participantsStarted Apr 2022

Duarte, California, United States • Pittsburgh, Pennsylvania, United States • Houston, Texas, United States +2 more locations

COMPLETEDPhase 2< 1 mile

Pleconaril Enteroviral Sepsis Syndrome

NCT00031512

A common group of viruses that infect humans are enteroviruses. Enteroviruses produce illnesses in children which may range from very mild (summer colds) to severe (infections of the brain, liver, and heart). The purpose of this study is to determine if a new drug called pleconaril helps treat babies with enteroviral sepsis. In addition, researchers are attempting to determine a safe and effective dose of pleconaril to help babies with this disease. Infants who are 15 days or younger when diagnosed with enteroviral disease are eligible for this study. Two out of 3 babies will be randomly assigned to receive Pleconaril and the other one out of three will receive a placebo (inactive substitute). Participants will be hospitalized while receiving study medication. Babies will receive standard treatment care for their symptoms and will be observed for their medical progress. Participants may be in the study for up to 2 years.

Enterovirus Infection

National Institute of Allergy and Infectious Diseases (NIAID)61 participantsStarted Jun 2001

Birmingham, Alabama, United States • Little Rock, Arkansas, United States • Los Angeles, California, United States +22 more locations

A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma

Pleconaril Enteroviral Sepsis Syndrome

Find Trials by Condition in Pittsburgh

Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults

PROSPECT: Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery

ILLUMENATE Pivotal Post-Approval Study (PAS)

OSE2101 Versus Chemotherapy in HLA-A2 Positive Patients With Advanced NSCLC After Immune Checkpoint Inhibitor Failure

Evaluation of Real-World Data on the Performance of the TECNIS Odyssey™ IOL

Efficacy Evaluation of VERU-111 for mCRPC in Patients Who Have Failed at Least One Androgen Receptor Targeting Agent

A Safety and Tolerability Study of Crenolanib in Combination With Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Patients With FLT3 Mutations

A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)

Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer

Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)

Study of XL184 (Cabozantinib) in Adults With Glioblastoma Multiforme

Tracheostomy Robotics and Cutting-edge Health Education for Airway Safety

EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

Study in Subjects With Small Primary Choroidal Melanoma

A Study of mRNA-1020 and mRNA-1030 Seasonal Influenza Vaccines in Healthy Adults

A Pharmacokinetics Study of MK-7655A in Pediatric Participants With Gram-negative Infections (MK-7655A-020)

Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer

Efficacy, Safety, and Tolerability of ATM-AVI in the Treatment of Serious Infection Due to MBL-producing Gram-negative Bacteria