A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma

Exclusion Criteria

• •1. Subjects with a history of brain metastases or who have signs/symptoms attributable to brain metastases and have not been assessed with radiologic imaging to rule out the presence of brain metastases. Subjects with treated brain metastases that are asymptomatic and have been clinically stable for at least 4 weeks will be eligible.
• •2. Subjects who have not received vaccines for severe acute respiratory syndrome-corona virus-2 (SARS-COV-2) and have suspected signs and symptoms of the novel coronavirus infection (COVID-19) or have confirmed COVID-19.
• •3. Subjects with a history of another primary malignancy, other than:
• •1. In situ carcinomas, e.g., breast, cervix, and prostate
• •2. Locally excised nonmelanoma skin cancer
• •3. No evidence of disease from another primary cancer for 2 or more years and has not taken any anti-cancer treatment in 2 years.
• •4. Any other clinically significant acute or chronic medical or psychiatric condition or any laboratory abnormality that may increase the risk associated with study drug administration or may interfere with the interpretation of study results.
• •5. Diseases that significantly affect GI absorption of CYC140.
• •6. Subjects who have impaired cardiac function or clinically significant cardiac disease.
• •7. Presence of active chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease) or GI perforation within 6 months of enrollment
• •8. Presence of an active infection requiring intravenous antibiotics
• •9. Presence of known history of human immunodeficiency virus-1/2 with uncontrolled viral load and on medications that may interfere with metabolism
• •10. Presence of active hepatitis B virus (HBV) or hepatitis C virus (HCV).
• •11. Chemotherapy, biologic therapy, targeted therapy, immunotherapy, extended-field radiotherapy, or investigational agents within 5 half-lives or 3 weeks (whichever is shorter) prior to administration of first dose of study drug on Day 1 or have not recovered from the side effects of such therapy.
• •12. Major surgery/surgical therapy for any cause within 4 weeks of the first dose