Clinical Trials in Pittsburgh

Showing 5421-5440 of 16,007 trials

Epigenetic Effects on Traumatic Brain Injury Recovery

NCT04186429

Methylation of the brain-derived neurotrophic factor (BDNF) gene is involved in both the biological encoding of childhood adversity and neuroplasticity following traumatic brain injury (TBI). This research will characterize BDNF methylation during recovery from TBI in children and investigate this novel biomarker as a potential biological mechanism underlying the known association between childhood adversity and poorer neurobehavioral outcomes following TBI in childhood. Findings from this research will contribute to an improved understanding of why some children display good recovery following TBI, whereas many others suffer from chronic neurobehavioral impairments.

Traumatic Brain InjuryOrthopedic Injury

University of Pittsburgh401 participantsStarted Jul 2017

Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 2< 1 mile

S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer

NCT02177695

The primary focus of this study is to see if looking at tumor biomarkers using a program called coexpression extrapolation or "COXEN" may predict a patient's response to chemotherapy before surgery.

Bladder Cancer

SWOG Cancer Research Network237 participantsStarted Aug 2014

Birmingham, Alabama, United States • Fairbanks, Alaska, United States • Phoenix, Arizona, United States +563 more locations

Epigenetic Effects on Traumatic Brain Injury Recovery

S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer

Find Trials by Condition in Pittsburgh

Staying Active With Arthritis: RCT of Physical Activity for Older Adults With Osteoarthritis and Hypertension

Open-Label, Phase 1 Study to Evaluate Duration of Severe Neutropenia After Same-Day Dosing of Eflapegrastim in Patients With Breast-Cancer

PARP Inhibition for Triple Negative Breast Cancer (ER-/PR-/HER2-)With BRCA1/2 Mutations

AI ENRICH - AI Detection of ICH

Long-term Safety of Lumacaftor/Ivacaftor in Participants With Cystic Fibrosis Who Are Homozygous for F508del and 12 to <24 Months of Age at Treatment Initiation

Air Optix® Night and Day® Aqua Continuous Wear

First-in-Human Study of EOS100850 (Inupadenant) in Patients with Cancer

Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors

Study to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload

A First-in-Human Study to Evaluate JCXH-105, an SrRNA-based Herpes Zoster Vaccine

Study to Evaluate Safety, Tolerability, PK and PD of DCR-PHXC in PH Type 3 Patients

Peer Mentorship to Improve Outcomes in Patients on Maintenance Hemodialysis

Clinical Trial Comparing C-Brace to Knee Ankle Foot Orthosis (KAFO)/Stance Control Orthosis (SCO)

A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release

Encore PFO Closure Device - The PerFOrm Trial

A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST

A Phase I/II Trial Investigating LOAd703 in Combination With Atezolizumab in Malignant Melanoma

A Study to Evaluate the Efficacy, Safety, and Concentration of SNS812 in Mild to Moderate COVID-19 Patients