Clinical Trials in Pittsburgh

Showing 3581-3600 of 14,892 trials

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal Melanoma

NCT03467516

This is a Phase 2 study in which the efficacy of a non-myeloablative lymphodepleting preparative regimen followed by infusion of autologous TIL and high-dose aldesleukin in patients with metastatic uveal melanoma will be evaluated. Metastatic uveal melanoma (UM) carries a poor prognosis with estimated survival of 4-6 months. There are no known effective systemic therapies. Metastatic UM is classified as an "orphan" disease and there are currently few clinical trial options for these patients. Thus, novel systemic approaches are desperately needed. A recent pilot study has found that administration of autologous tumor infiltrating lymphocytes (TIL) generated from resected metastases can induce objective tumor response and durable complete response in metastatic uveal melanoma patients. These encouraging results require confirmation to determine if this immunotherapy is of future benefit in treating this disease.

Uveal NeoplasmsMelanoma, Uveal

Udai Kammula47 participantsStarted May 2018

Pittsburgh, Pennsylvania, United States

TERMINATEDPhase 2< 1 mile

89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors

NCT05563272

A prospective, open-label, phase 2 study to explore CAIX expression through 89Zirconium-labelled girentuximab deferoxamine (89Zr-girentuximab) PET/CT imaging in patients with solid tumors.

Cervical CancerColorectal CancerEsophageal Cancer+16 more

Telix Pharmaceuticals (Innovations) Pty Ltd11 participantsStarted Jun 2023

Los Angeles, California, United States • Miami, Florida, United States • Boston, Massachusetts, United States +7 more locations

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal Melanoma

89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors

Find Trials by Condition in Pittsburgh

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

Real-time NOMA Evaluation

Ravulizumab Versus Placebo in Adult Participants With Dermatomyositis

Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

A Study of JNJ-55308942 in the Treatment of Bipolar Depression

Study of Front Line Therapy With Nivolumab and Salvage Nivolumab + Ipilimumab in Patients With Advanced Renal Cell Carcinoma

The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)

MCG as a Noninvasive Diagnostic Strategy for Suspected INOCA (MICRO2)

Herbs & Supplements in Breast Cancer Usage, Impact, and Personalized Approaches for Diverse Populations

Study of mRNA-1010 Seasonal Influenza Vaccine in Adults

Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)

A Study to Investigate the Safety and Efficacy of TMP-301 Compared to Placebo in Adult Patients With Alcohol Use Disorder

A Study of INCB050465 in Participants With Autoimmune Hemolytic Anemia

Observational Maternal COVID-19 Vaccination Study

A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19)

AutoInflammatory Disease Alliance Registry (AIDA)

Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)