Clinical Trials in Pittsburgh

Showing 2921-2940 of 21,047 trials

Early Intervention for Youth at High Risk for Bipolar Disorder

NCT04815239

Investigators will conduct a confirmatory efficacy trial of Interpersonal and Social Rhythm Therapy (IPSRT) delivered via telehealth for offspring of bipolar parents (OBP; age 12-18, n=120) at elevated risk for BP onset via risk calculator score. All participants receive a baseline clinical assessment of psychiatric symptoms and sleep disturbance (via objective and subjective methods), followed by a feedback session. Youth are then randomized to receive 8 sessions of IPSRT or a manualized Healthy Lifestyle Behaviors Program (HL) delivered via secure videoconference. As clinically indicated, youth are offered Community Treatment Referral (CTR) for any psychiatric symptoms/disorders identified at intake. Primary outcome domains over 18 months include mania and affective lability. Investigators will also further investigate the hypothesized mechanism underlying IPSRT (i.e., sleep/circadian disruption) across levels of analysis, and the contribution of interpersonal stress to sleep/circadian disruptions. Application of Implementation Science methods throughout maximizes ultimate scalability and feasibility if efficacious. Investigators will also examine whether passive cellphone sensing may serve as a portable, cost-effective measure of mechanisms and outcomes to enhance ultimate dissemination.

Bipolar Disorder

University of Pittsburgh120 participantsStarted Sep 2021

Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 3< 1 mile

A 12-week Study to Assess the Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler in Participants With Inadequately Controlled Asthma (LITHOS)

NCT05755906

This is a 12-week study to evaluate the efficacy and safety of budesonide and formoterol fumarate metered dose inhaler relative to budesonide metered dose inhaler in adults and adolescents with inadequately controlled asthma.

Asthma

AstraZeneca374 participantsStarted Feb 2023

Chandler, Arizona, United States • Mesa, Arizona, United States • Tucson, Arizona, United States +101 more locations

Early Intervention for Youth at High Risk for Bipolar Disorder

A 12-week Study to Assess the Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler in Participants With Inadequately Controlled Asthma (LITHOS)

Find Trials by Condition in Pittsburgh

Clinical Study of the Treovance Stent-Graft for Patients With Abdominal Aortic Aneurysms

A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.

Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot Ulcers

A Study of Enasidenib in People With Clonal Cytopenia of Undetermined Significance

Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults.

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment

Initiating Early Control of Migraine Pain and Associated Symptoms

More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in HIV-Infected Children and Adolescents

A Placebo-controlled Safety and Tolerability Study of Intravenous (IV) and Subcutaneous (SC) AZD1163 in Healthy Volunteers

Motivational Interviewing to Address Suicidal Ideation for Veterans at High Risk for Suicide

Study of GS-4528 in Adults With Solid Tumors

LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)

The Thrive Study: Improving Multimodal Physical Function in Adults With Heterogenous Chronic Pain

EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

Evaluating BOSCC and ELSA as Outcome Measures in the Context of a JASPER Intervention Trial