Clinical Trials in Pittsburgh

Showing 2901-2920 of 21,047 trials

Early Intervention for Youth at High Risk for Bipolar Disorder

NCT04815239

Investigators will conduct a confirmatory efficacy trial of Interpersonal and Social Rhythm Therapy (IPSRT) delivered via telehealth for offspring of bipolar parents (OBP; age 12-18, n=120) at elevated risk for BP onset via risk calculator score. All participants receive a baseline clinical assessment of psychiatric symptoms and sleep disturbance (via objective and subjective methods), followed by a feedback session. Youth are then randomized to receive 8 sessions of IPSRT or a manualized Healthy Lifestyle Behaviors Program (HL) delivered via secure videoconference. As clinically indicated, youth are offered Community Treatment Referral (CTR) for any psychiatric symptoms/disorders identified at intake. Primary outcome domains over 18 months include mania and affective lability. Investigators will also further investigate the hypothesized mechanism underlying IPSRT (i.e., sleep/circadian disruption) across levels of analysis, and the contribution of interpersonal stress to sleep/circadian disruptions. Application of Implementation Science methods throughout maximizes ultimate scalability and feasibility if efficacious. Investigators will also examine whether passive cellphone sensing may serve as a portable, cost-effective measure of mechanisms and outcomes to enhance ultimate dissemination.

Bipolar Disorder

University of Pittsburgh120 participantsStarted Sep 2021

Pittsburgh, Pennsylvania, United States

RECRUITINGPhase 311 miles

Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

NCT05904028

Home optical coherence tomography- guided treatment versus treat and extend for the management of neovascular age-related macular degeneration.

Neovascular Age-related Macular Degeneration

Jaeb Center for Health Research600 participantsStarted Nov 2023

Glendale, California, United States • Loma Linda, California, United States • Oakland, California, United States +61 more locations

Early Intervention for Youth at High Risk for Bipolar Disorder

Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

Find Trials by Condition in Pittsburgh

Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors

Sorafenib Tosylate With or Without Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer

Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults.

A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH

Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

An Open Label, Randomized Study of Neoadjuvant Nivolumab and Chemotherapy, With or Without Sub-ablative Stereotactic Body Radiation Therapy, for Resectable Stage IIA to IIIB Non-small Cell Lung Cancer

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

Study of GS-4528 in Adults With Solid Tumors

TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

The Thrive Study: Improving Multimodal Physical Function in Adults With Heterogenous Chronic Pain

A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)

EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA

BCL2i CLAG-M in R/R Acute Myeloid Leukemia

R-3750 in Patients With Mild to Moderate Ulcerative Colitis

Early Onset Colorectal Cancer Detection