Clinical Trials in Pittsburgh

Showing 1981-2000 of 10,050 trials

Precision Analgesia for Cardiac Surgery

NCT05612399

The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone in elderly adults undergoing cardiac surgery.

AnalgesiaCardiac Surgery

Kathirvel Subramaniam400 participantsStarted Apr 2026

Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 2< 1 mile

A Study to Assess Vamorolone in Becker Muscular Dystrophy (BMD)

NCT05166109

This Phase II pilot study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, PD, and exploratory clinical efficacy of vamorolone 500mg (250mg for body weight \<50 kg) daily administered orally compared to placebo over a treatment period of 24 weeks in males with BMD. Funding Source - FDA OOPD

Becker Muscular Dystrophy

ReveraGen BioPharma, Inc.46 participantsStarted Jul 2022

Pittsburgh, Pennsylvania, United States • Padua, Italy

Active Not RecruitingPhase 3< 1 mile

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

NCT05382286

The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1).

Triple Negative Breast CancerPD-L1 Positive

Gilead Sciences443 participantsStarted Jul 2022

Anchorage, Alaska, United States • Tucson, Arizona, United States • Tucson, Arizona, United States +501 more locations

Precision Analgesia for Cardiac Surgery

A Study to Assess Vamorolone in Becker Muscular Dystrophy (BMD)

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

Find Trials by Condition in Pittsburgh

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III)

EASE: The Materna Prep Pivotal Study

A Study of Danavorexton in People With Obstructive Sleep Apnea After General Anesthesia for Abdominal Surgery

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VYN201 Gel in Subjects With Non-segmental Vitiligo.

sipIT2: Improving Adherence to Fluid Intake Guidelines for Kidney Stone Prevention

Locking Plates for Distal Femur Fractures - a Multicenter Case Review

Device for Improving Skin Quality and Texture on the Face and Neck

Omnipod 5 System Compared to Pump Therapy

Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer

Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders

A Study of Auxora in Patients With Severe COVID-19 Pneumonia

Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B

Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer

An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation

Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs