Clinical Trials in Phoenix

Showing 6841-6860 of 16,646 trials

A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens

NCT03953235

The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. Based on the Phase 1 data, an updated vaccine candidate (SLATE-KRAS or version 2) was developed that removed 16 of the 20 mutations included in the original vaccine (version 1) and solely targets KRAS mutations.

Non-Small Cell Lung CancerColorectal CancerPancreatic Cancer+2 more

Gritstone bio, Inc.39 participantsStarted Jul 2019

Phoenix, Arizona, United States • Santa Monica, California, United States • Jacksonville, Florida, United States +9 more locations

COMPLETEDPhase 3< 1 mile

Study of the Safety and Efficacy of PRX-102 Compared to Agalsidase Beta on Renal Function

NCT02795676

This was a randomized, double-blind, active control study of the enzyme replacement therapy (ERT) drug PRX-102 (pegunigalsidase alfa) in Fabry disease patients with impaired renal function. Patients who had been treated for approximately 1 year with agalsidase beta and who had been on a stable dose of that product for at least 6 months were randomized in a 2:1 ratio to either switch to PRX-102 or to continue treatment with agalsidase beta. Both treatments were delivered by intravenous infusions every two weeks, at a dosage of 1 mg/kg.

Fabry Disease

Protalix78 participantsStarted Jun 2016

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Orange, California, United States +26 more locations

A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens

Study of the Safety and Efficacy of PRX-102 Compared to Agalsidase Beta on Renal Function

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Addressing Dementia Via Agitation-Centered Evaluation

Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex

Study of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Patients With Metastatic Breast Cancer (MK-7962-012)

Impact of Acetaminophen on Performance of Guardian™ Sensor (3) in Adults

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

Safety & Efficacy of Pilocarpine Ophthalmic Spray for Temporary Improvement of Near Vision in Presbyopic Adults

Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis

Dociparstat Sodium (CX-01) Combined With Standard Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia

Real World Evaluation of the Effectiveness of AZD7442 for Prevention of SARS-CoV-2

A Phase 1b Study to Evaluate APL-1401 in Patients With Moderately to Severely Active Ulcerative Colitis

A Long-Term Extension Trial in Participants With Atopic Dermatitis Who Participated in Previous EDP1815 Trials

Efficacy and Safety of Orally Administered BBT-401-1S in Subjects With Ulcerative Colitis

Consolidation Pembrolizumab Following Chemoradiation in Patients With Inoperable/Unresectable Stage III NSCLC

PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer

Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

A Study of Duvelisib in Participants With Refractory Indolent Non-Hodgkin Lymphoma

Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy