Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

Exclusion Criteria

• •History of an allergic reaction to any xanthine-containing substance.
• •History of seizure
• •History of stroke
• •Myocardial infarction
• •Uncorrected hemodynamically significant primary valvular disease or known Obstructive or restrictive cardiomyopathy.
• •Serious systemic infection
• •Major surgical procedures within 30 days
• •Acute coronary syndrome
• •Cardiogenic shock
• •Baseline body weight \>150 kg
• •Participation in any other investigational study of drugs or devices within 30 days prior to Screening
• •Nursing mothers, pregnant women, or women planning on becoming pregnant during the study
• •Presence of any clinically significant condition that might interfere with optimal safe participation in this study