History of an allergic reaction to any xanthine-containing substance.

History of seizure

History of stroke

Myocardial infarction

Uncorrected hemodynamically significant primary valvular disease or known Obstructive or restrictive cardiomyopathy.

Serious systemic infection

Major surgical procedures within 30 days

Acute coronary syndrome

Cardiogenic shock

Baseline body weight \>150 kg

Participation in any other investigational study of drugs or devices within 30 days prior to Screening

Nursing mothers, pregnant women, or women planning on becoming pregnant during the study

Presence of any clinically significant condition that might interfere with optimal safe participation in this study

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency