A Phase 1b Study to Evaluate APL-1401 in Patients With Moderately to Severely Active Ulcerative Colitis

Exclusion Criteria

• •1. Has fulminant colitis, toxic megacolon, primary sclerosing cholangitis, Crohn's disease, history of colitis-associated colonic dysplasia, active peptic ulcer disease.
• •2. Has a current clinically significant bacterial, parasitic, fungal, or viral infection.
• •3. Is positive for hepatitis A, B or C, human immunodeficiency virus (HIV), or tuberculosis.
• •4. Uses any of the following medications:
• •1. Intravenous corticosteroids 1 week prior to randomization;
• •2. Topical 5-ASA compounds or topical steroid (i.e., enemas or suppositories) 2 weeks prior to randomization;
• •3. Anti-diarrheal medications 2 weeks prior to randomization;
• •4. Sphingosine 1-phosphate receptor (S1PR) modulator including ozanimod 9 prior to randomization;
• •5. JAK inhibitors including tofacitinib and upadacitinib 4 weeks prior to randomization;
• •6. TNF-α antagonist including (but not limited to) infliximab, adalimumab, golimumab, certolizumab, or biosimilar agents 10 weeks prior to randomization;
• •7. Integrin antagonist, including vedolizumab 18 weeks prior to screening and natalizumab 10 weeks prior to screening;
• •8. Interleukin antagonist including ustekinumab 14 weeks prior to screening;
• •9. Patients receiving any of the following medications, if they were not discontinued at least 2 weeks prior to randomization: azathioprine, 6-mercaptopurine, methotrexate, mycophenolate mofetil, cyclosporine, tacrolimus, sirolimus, thalidomide. See Table 1;
• •10. Prohibited concomitant medications as described in Section 6.5.2 Table 1.
• •5. Participated in another clinical study of an investigational drug (or medical device) within 30 days prior to screening or is currently participating in another study of an investigational drug (or medical device).
• •6. Has clinically significant abnormalities in laboratory tests (complete blood count, chemistry panel, TSH, total T3, free T4, urinalysis
• •1. Hepatic panel (AST, ALT, total bilirubin) \>2 times the upper limits of normal (ULN)
• •2. Estimated CrCl \<60 mL/min as calculated by the Cockcroft-Gault equation
• •3. Thyroid stimulating hormone (TSH) \<2.5 mIU/L or \>4.2 mIU/L
• •7. Has a resting heart rate (HR) of \<50 bpm or \>120 bpm.
• •8. Has a resting systolic blood pressure \>160 mmHg or \<90 mmHg.
• •9. With thyroid disease or history thyroid surgery or on thyroid medications
• •10. Has orthostatic hypotension (decrease in systolic blood pressure \>20 mmHg or decrease in diastolic blood pressure \>10 mmHg when going from supine to standing) or a history of clinically significant orthostatic dizziness.
• •11. Treatment with Class Ia or Class III anti-arrhythmic drugs or treatment with two or more agents in combination known to prolong PR interval.
• •12. Is taking concomitant beta-blockers (including ophthalmologic timolol), amiodarone, reserpine, clonidine, monoamine oxidase (MAO) inhibitors, alpha blocking drugs, vasodilators which could enhance the production of catecholamines (hydralazine and nitrates), substrates or inhibitors of N-acetyltransferase.
• •13. Alcohol abuse or alcohol dependence at least 3 months prior to first dose.
• •14. With history of drug-related rash or has clinically significant rash or pruritus.
• •15. Has severe COVID-19 infection and needs to use ventilator or other treatments that make using of study drug impossible.
• •16. With moderate to severe (Child-Pugh Class B and Class C) hepatic impairment.