Clinical Trials in Philadelphia

Showing 1161-1180 of 9,968 trials

Evaluation of Outcome Metrics in Alexander Disease

NCT02714764

The purpose of this study is to define the natural history of Alexander Disease, a leukodystrophy that causes neurological dysfunction. Investigators will obtain clinical outcome assessments to measure how the disease affects a patient's gross motor, fine motor, speech and language function, swallowing, and quality of life. Specimens are collected to measure glial fibrillary acidic protein (GFAP) levels in cerebrospinal fluid (CSF) and blood. The data obtained from this study will be used for the design of future treatment trials.

Alexander Disease

Children's Hospital of Philadelphia200 participantsStarted Jan 2016

Philadelphia, Pennsylvania, United States

RECRUITINGNA< 1 mile

Assessment of CCM in HF With Higher Ejection Fraction

NCT05064709

The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

Heart FailureHeart Failure With Preserved Ejection FractionHeart Failure With Mid Range Ejection Fraction+2 more

Impulse Dynamics1,500 participantsStarted Feb 2022

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Mesa, Arizona, United States +109 more locations

Evaluation of Outcome Metrics in Alexander Disease

Assessment of CCM in HF With Higher Ejection Fraction

Find Trials by Condition in Philadelphia

Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression

Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity

Beta-cell Response to Incretin Hormones in Cystic Fibrosis

Immersive Virtual Reality vs Treadmill Exercise Project

A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Cytoreductive Surgery

A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC)

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

The EVARREST® Pediatric Mild or Moderate Liver and Soft Tissue Bleeding Study

A Phase 1b/2, Multi-center, Single Arm Study to Assess the Safety and Efficacy of Neoantigen Synthetic Long Peptide Vaccines in Patients With Local Or Metastatic Solid Tumors

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and Granulocyte Colony Stimulating Factor (G-CSF) as Compared to Placebo and G-CSF for the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Subjects With Multiple Myeloma (MM)

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Prostate Active Surveillance Study

A Study of Cytisinicline for Smoking Cessation in Adult Smokers

Harm Reduction for Smokers With Mental Illness

Study of Serine Supplementation to Protect Vision in MacTel