Clinical Trials in Philadelphia

Showing 10341-10360 of 17,926 trials

Photodynamic Therapy for Cutibacterium Acnes (C. Acnes) Decolonization of the Shoulder Dermis

NCT04636242

This is a prospective, randomized controlled trial to evaluation the ability of 5-aminolevulinic acid HCL topical solution photodynamic therapy to decrease the colonization of Cutibacterium acnes (C. acnes- a bacteria commonly found in the dermis of the skin surrounding the shoulder) in order to decrease postoperative joint infections. -Aminolevulinic acid (ALA) is a naturally occurring metabolite in the synthesis of pathway of cellular heme production. Adding ALA to bacteria encourages porphyrin production which serve as the immediate precursors to heme production. When these porphyrins are illuminated with blue light at an emission peak of 407-420nm, these metabolites become exothermic and cause internal destruction of the bacterial cells. This therapy does not cause any damage to the mammalian cells, which makes PDT safe for human skin treatment.

C. AcnesPhototherapyPostoperative Infection+2 more

Rothman Institute Orthopaedics120 participantsStarted Aug 2019

Philadelphia, Pennsylvania, United States

COMPLETEDNA< 1 mile

TRANSFIX Zenith® Transection Clinical Study

NCT01688050

The TRANSFIX study is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® TX2® Low Profile Endovascular Graft for treatment of Blunt Thoracic Aortic Injury.

Thoracic AortaThoracic InjuriesBlunt Injuries

Cook Research Incorporated50 participantsStarted Jan 2013

Little Rock, Arkansas, United States • Los Angeles, California, United States • Los Angeles, California, United States +18 more locations

Photodynamic Therapy for Cutibacterium Acnes (C. Acnes) Decolonization of the Shoulder Dermis

TRANSFIX Zenith® Transection Clinical Study

Find Trials by Condition in Philadelphia

Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc)

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Health Care Hotspotting: A Randomized Controlled Trial

Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease

Study Comparing the Safety and Efficacy of Two Doses of BC-3781 vs Vancomycin in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies

Assessment of the Ability of Subjects With Acromegaly or Their Partners to Administer Somatuline Autogel

A Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)

Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE

Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome

A Phase 2 Study to Evaluate the Safety and Efficacy of Intravenously Administered Benralizumab (MEDI-563).

Patient Centered Results for Uterine Fibroids

Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Participants (DARWIN1)

Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure

Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye

Role of Circulating Tumor DNA (ctDNA) From LIquid Biopsy in Early Stage NSCLC Resected Lung Tumor Investigation

PRISM: Efficacy and Safety of Cobomarsen (MRG-106) in Subjects With Mycosis Fungoides Who Have Completed the SOLAR Study

Exploring the Optimal Duration of a Group-based Online Behavioral Weight Loss Program