Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy

Exclusion Criteria

• •History of severe or life-threatening anaphylaxis within 60 days before screening
• •History of non-IgE mediated hen egg allergy such as food protein-induced enterocolitis syndrome (FPIES)
• •History of eosinophilic esophagitis (EoE), other eosinophilic gastrointestinal disease, chronic, recurrent, or severe gastroesophageal reflux disease (GERD), symptoms of dysphagia or recurrent gastrointestinal symptoms of unknown etiology
• •History of a mast cell disorder including systemic mastocytosis, urticaria pigmentosa, chronic idiopathic or chronic physical urticaria beyond simple dermatographism (e.g., cold urticaria, cholinergic urticaria), and hereditary or idiopathic angioedema
• •History of chronic disease (except asthma, atopic dermatitis, or allergic rhinitis) which may require a change in immunosuppressive medication regimen or chronic corticosteroid use
• •History of cardiovascular disease, including uncontrolled or inadequately controlled hypertension
• •Developing dose-limiting symptoms to placebo challenge during the Screening DBPCFC
• •Having the same place of residence as another subject in the study
• •Any other condition that, in the opinion of the Investigator, precludes participation for reasons of safety