Clinical Trials in Philadelphia

Showing 8761-8780 of 15,860 trials

RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM

NCT04433078

The primary aim of this study is to test whether Doxycycline can benefit patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by inhibiting the replication of the virus while at the same time blocking the development of cytokine storms or inhibiting cytokine-associated coagulopathy respectively. The investigators hypothesize that Doxycycline will will improve survival and reduce morbidity in SARS-CoV-2 infected patients. A secondary aim is to identify genetic variants that predict either an unusually mild disease or an unusually severe disease - knowledge that can be used to design new and precise medications and to be able to predict patients who might get into early trouble and to therefore hospitalize them.

Cytokine StormSARS-CoV-2

Temple UniversityStarted Jun 2020

Philadelphia, Pennsylvania, United States

COMPLETED< 1 mile

A Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor

NCT02787213

Prospective multicenter observational study to further develop and validate a preterm birth risk predictor, using a preterm cutoff at 37 0/7 weeks gestation and at 35 0/7 weeks gestation. A single maternal peripheral blood sample will be collected for analysis. Data related to potential risk factors for preterm birth will be obtained through maternal interview and review of medical records. Subjects will be followed through the delivery process to assess the course of pregnancy, labor, and to document any related maternal complications. Neonatal outcomes will be gathered from the medical record for up to 28 days of life or discharge, whichever occurs first.

Preterm Birth

Sera Prognostics, Inc.5,011 participantsStarted Aug 2016

Phoenix, Arizona, United States • Orange, California, United States • San Diego, California, United States +15 more locations

RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM

A Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor

Find Trials by Condition in Philadelphia

A Safety Extension Study With Benralizumab for Asthmatic Adults on Inhaled Corticosteroid Plus Long-acting β2 Agonist

Open-Label Study to Evaluate Safety of A Single Dose of SYM-1219

Interferon Gamma-1b in Friedreich Ataxia (FRDA)

Rheos System for the Treatment of HFpEF Heart Failure

A Safety, Efficacy and Pharmacokinetics Study of CD11301 for the Treatment of Cutaneous T-Cell Lymphoma (CTCL)

Depression Prevention Initiative - A Study of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) in School Settings

ARQ 197 for Participants With Relapsed or Refractory Germ Cell Tumors

A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)

Focus Group in Collecting Feedbacks From Indoor Tanning Bed Users for Social Media-Delivered Intervention Development

Collecting and Storing Blood and Tumor Tissue Samples From Patients Undergoing Prostatectomy or Transurethral Resection of the Prostate

Cytoreductive Prostatectomy in Treating Patients With Newly Diagnosed, Metastatic Prostate Cancer

Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners

UNITE Study: Understanding New Interventions With GBM ThErapy

A Study to Evaluate Next-Dose Transition From Zolpidem to Lemborexant (LEM) for the Treatment of Insomnia

A Phase II Study of M2951 in SLE

A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function

Clinical Study to Evaluate the Maximum Tolerated Dose of BAY1000394 When Given Together With Chemotherapy and the Effectiveness of This Combination Treatment in Shrinking a Specific Type of Lung Tumors (Small Cell Lung Cancer)

Refametinib in Combination With Sorafenib in RAS Mutant Hepatocellular Carcinoma (HCC)