Clinical Trials in Philadelphia

Showing 4661-4680 of 15,860 trials

Optical Coherence Tomography (OCT) Reference Data Collection Study (S-2015-3)

NCT02785042

This prospective, single-arm clinical multicenter study intends to measure normal structural parameters of the optic nerve head, the peripapillary retinal nerve fiber layer, and the macula using the Heidelberg Spectralis OCT device. This study is conducted in Hispanic descent volunteers. The main goal of the study is to provide the range of these structural parameters in normal eyes. The study will include at least 240 normal volunteers.

Glaucoma

Heidelberg Engineering GmbH224 participantsStarted Jun 2016

La Jolla, California, United States • Santa Monica, California, United States • Santa Rosa, California, United States +5 more locations

COMPLETEDPhase 1< 1 mile

Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors

NCT05225584

This Phase 1a/1b study will evaluate the safety, tolerability and the pharmacokinetics/pharmacodynamics (PK/PD) of KT-333 in Adult patients with Relapsed or Refractory (R/R) Lymphomas, Large Granular Lymphocytic Leukemia (LGL-L), T-cell prolymphocytic leukemia (T-PLL), and Solid Tumors. The Phase 1a stage of the study will explore escalating doses of single-agent KT-333. The Phase Ib stage will consist of 4 expansion cohorts to further characterize the safety, tolerability and the pharmacokinetics/pharmacodynamics (PK/PD) of KT-333 in Peripheral T-cell Lymphoma (PTCL), Cutaneous T-Cell Lymphoma (CTCL), LGL-L, and solid tumors.

Non Hodgkin Lymphoma (NHL)Peripheral T-cell Lymphoma (PTCL)Cutaneous T-Cell Lymphoma (CTCL)+3 more

Kymera Therapeutics, Inc.56 participantsStarted May 2022

Orange, California, United States • Louisville, Kentucky, United States • Detroit, Michigan, United States +10 more locations

Optical Coherence Tomography (OCT) Reference Data Collection Study (S-2015-3)

Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors

Find Trials by Condition in Philadelphia

Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors

BIOTRONIK Conduction System Pacing With the Solia Lead

p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

EVAS2 IDE Prospective, Multicenter, Single Arm Safety and Effectiveness Confirmatory Study

A Study of LY3561774 in Participants With Mixed Dyslipidemia

A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer

A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy

PF-06863135 As Single Agent And In Combination With Immunomodulatory Agents In Relapse/Refractory Multiple Myeloma

A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases

A Study of Etigilimab and Nivolumab in Participants With Locally Advanced or Metastatic Tumors

Method Comparison Study for Measuring Potassium (K) and Ionized Calcium (iCa) in Blood

Precision Study Measuring Potassium (K) in Capillary Specimens

SG2501 Safety Study in Subjects with Relapsed or Refractory Hematological Malignancies and Lymphoma.

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women

Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5410 in Adult Participants 18 Years of Age and Older

Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT411

A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure