Clinical Trials in Philadelphia

Showing 4161-4180 of 15,860 trials

Itacitinib + Everolimus in Hodgkin Lymphoma

NCT03697408

This is an open-label, single-group, Phase I/II study of itacitinib in combination with everolimus in subjects with relapsed or refractory classical Hodgkin lymphoma (cHL).

Classical Hodgkin Lymphoma

University of Pennsylvania23 participantsStarted Feb 2019

Philadelphia, Pennsylvania, United States

COMPLETEDPhase 2< 1 mile

A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures

NCT04244175

The goal of this clinical trial is to learn if CVL-865, when taken regularly with other anti-seizure medicines, works to prevent seizures in adults with drug-resistant focal onset seizures. It will also learn about the safety of CVL-865. The main question it aims to answer is whether CVL-865, when taken regularly with other anti-seizure medicines, lowers the number of seizures in those with a diagnosis of epilepsy with drug-resistant focal onset seizures. This study has an 8-week Screening/Baseline Period, a 13-week Treatment Period (including a 2-week Titration Phase, an 8-week Maintenance Phase, and a 3-week Taper Phase), and a 4-week Safety Follow-Up Period. Participants will take CVL-865 or a placebo twice a day during the 10-13 week Treatment Period, visit the clinic every few weeks for checkups, tests, and surveys, and fill out an e-Diary.

Seizures

AbbVie154 participantsStarted Jan 2020

Little Rock, Arkansas, United States • Downey, California, United States • Loma Linda, California, United States +73 more locations

Itacitinib + Everolimus in Hodgkin Lymphoma

A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures

Find Trials by Condition in Philadelphia

Randomized Therapy In Status Epilepticus

A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos

Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy

SPIROMICS Study of Early COPD Progression (SOURCE)

Trial of Magrolimab (Hu5F9-G4) in Combination With Rituximab or Rituximab + Chemotherapy in Participants With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain

An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism

Flexiva Pulse Registry

Talazoparib and Axitinib for People With Previously Treated Advanced Kidney Cancer

Spatz3 Adjustable Balloon System® (Spatz3) Post Approval Study

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

HEALing Communities Study

Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

Modifiers of Disease Severity in Cerebral Cavernous Malformations

Evaluation of Oral ORIN1001 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

BE WELL With Migraine: Brain Education and WELLness With Migraine

Safety and Tolerability of M254 in Healthy Volunteers and Immune Thrombocytopenic Purpura (ITP) Patients