Clinical Trials in Philadelphia

Showing 3461-3480 of 15,860 trials

A Double-blind Study to Evaluate the Safety of Glutamic Acid Decarboxylase Gene Transfer in Parkinson's Participants

NCT05603312

The objective of this clinical trial was to evaluate the safety and tolerability of adeno-associated virus (AAV)-mediated delivery of glutamic acid decarboxylase (GAD) gene transfer into the subthalamic nuclei (STN) of participants with Parkinson's Disease.

Parkinson's Disease

MeiraGTx, LLC14 participantsStarted Oct 2022

New Haven, Connecticut, United States • West Bloomfield, Michigan, United States • New York, New York, United States +3 more locations

TERMINATEDPhase 2< 1 mile

A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

NCT05019521

This is a dose finding study designed to evaluate the efficacy, safety, and pharmacokinetics of danicopan in participants with GA secondary to AMD. The study consists of a Screening Period of up to 6 weeks, a 104-week masked Treatment Period, followed by a 30-day Follow-up after the last dose. This study will have 4 treatments arms: 100 milligrams (mg) twice daily (bid), 200 mg bid, 400 mg once daily (qd), and matching placebo.

Geographic Atrophy

Alexion Pharmaceuticals, Inc.365 participantsStarted Aug 2021

Phoenix, Arizona, United States • Beverly Hills, California, United States • Encino, California, United States +125 more locations

A Double-blind Study to Evaluate the Safety of Glutamic Acid Decarboxylase Gene Transfer in Parkinson's Participants

A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Find Trials by Condition in Philadelphia

Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-827104 in Pediatric Subjects With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep

QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

Expanded Access Program for Revumenib

Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

SHAPE for ICP Assessment

Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis

A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy

Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial

GV1001 Subcutaneous(SC) for the Treatment of Mild to Moderate Alzheimer's Disease (AD)

Proton Radiation for Stage II/III Breast Cancer

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection and Drugs-induced Osteonecrosis

Tapinarof for the Treatment of Atopic Dermatitis in Children and Adults

A Study of TAK-676 With Pembrolizumab After Radiation Therapy to Treat a Number of Cancers

Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial

A Study in the United Sates That Looks at the Safety and Effectiveness of Pradaxa Pellets in Children Aged 3 Months to Less Than 12 Years Who Need Treatment of a Blood Clot or Who Have Had a Blood Clot and Are at Risk of Developing Another Blood Clot

Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who Require More Than Eight Weeks of Omegaven Treatment

The PLATFORM Study: Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts)