Clinical Trials in Pennsylvania

Showing 9501-9520 of 14,950 trials

Surgical Study Comparing 2 Procedures for the Treatment of a Dropped Bladder

NCT00271102

The purpose of this study is to determine whether vaginal repair or abdominal repair is the procedure of choice for the surgical management of a prolapsed bladder.

Prolapse

Geisinger Clinic70 participantsStarted Jan 2006

Danville, Pennsylvania, United States

COMPLETEDPhase 240 miles

VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

NCT01666444

The purpose of this study is to compare the overall survival of patients treated with VTX-2337 + pegylated liposomal doxorubicin (PLD) versus those treated with PLD alone in women with recurrent or persistent, epithelial ovarian, fallopian tube or primary peritoneal cancer. VTX-2337, a small molecule agonist of Toll-like Receptor 8 (TLR8), activates multiple components of the innate immune system and is being developed as a novel therapeutic agent for use in oncology. Experimental data obtained in an animal model of ovarian cancer supports the combination of VTX-2337 with PLD. In this model, the combination of VTX-2337 and PLD resulted in a significant reduction in tumor growth compared to either agent alone and an increase in the number of T lymphocytes infiltrating the tumor. The combination of PLD and VTX-2337 has been tested in a small number of women with ovarian cancer in a Phase 1b study and appears to be generally well-tolerated.

Epithelial Ovarian CancerFallopian Tube CancerPrimary Peritoneal Cancer

Celgene297 participantsStarted Oct 2012

Phoenix, Arizona, United States • Little Rock, Arkansas, United States • Burbank, California, United States +133 more locations

Surgical Study Comparing 2 Procedures for the Treatment of a Dropped Bladder

VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Find Trials by Condition in Pennsylvania

A Study in Second Line Metastatic Colorectal Cancer

Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III

Study of Ramucirumab in Ovarian Cancer

MRI to Detect Breast Tumors in Women

A Study of Lampalizumab Intravitreal Injections Administered Every Two Weeks or Every Four Weeks to Participants With Geographic Atrophy

A Study to Test Safety and Efficacy of Baricitinib in Participants With Diabetic Kidney Disease

ERADICATE Hp - Treating Helicobacter Pylori With RHB-105

Open Label Extension Study to Evaluate the Long-term Safety of Zorblisa (SD-101-6.0) in Patients With Epidermolysis Bullosa

Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)

Acalabrutinib (ACP-196) Alone and in Combination With Pembrolizumab in Ovarian Cancer (KEYNOTE191)

A Study in Participants With Moderate to Severe Psoriasis

MRI for Detecting Cancer in Women Who Are at High Risk of Developing Breast Cancer

Safety and Feasibility of ADRCs Treatment To Patients With Thermal Wounds

A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)

A Study in Advanced Solid Tumors

Efficacy and Safety of Daclizumab in Participants With RRMS Switching From Natalizumab

A Study of Gemcitabine-Carboplatin Plus Necitumumab (LY3012211) in Chemotherapy-Naïve Participants With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)

Study of RTXM83 Plus CHOP Chemotherapy Versus a Rituximab Plus CHOP Therapy in Patients With Non Hodgkin's Lymphoma