Clinical Trials in Ohio

Showing 3881-3900 of 17,983 trials

Immune Suppression and Ventilator Associated Pneumonias

NCT01135277

Patients in the ICU are already predisposed to nosocomial infections, which are both costly and potentially life threatening, and it appears that the immune paralysis of sepsis may put these patients at greater risk for secondary infections, though this has not been proven conclusively. One measure of this sepsis-induced immune suppression is monocyte deactivation. The investigators hypothesize that, as a cornerstone of the monocytic innate immune response to infection, the inflammasome is critical to monocyte function during sepsis.

Sepsis

Matthew Exline50 participantsStarted Feb 2010

Columbus, Ohio, United States

COMPLETEDPhase 332 miles

A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease

NCT03729362

This is a phase 3 double-blind randomized study to study the efficacy and safety of intravenous ATB200 Co-administered with oral AT2221 in adult subjects with Late Onset Pompe Disease compared with Alglucosidase Alfa/placebo.

Pompe Disease (Late-onset)

Amicus Therapeutics125 participantsStarted Dec 2018

Phoenix, Arizona, United States • Little Rock, Arkansas, United States • Irvine, California, United States +70 more locations

Immune Suppression and Ventilator Associated Pneumonias

A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease

Find Trials by Condition in Ohio

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug

Nature IDEAS Study: An RCT to Increase Time Spent in Nature Among University Students

Inactivated Split Virus Seasonal Influenza Vaccine (Vero Cell-Derived)

Study of Lademirsen (SAR339375) in Patients With Alport Syndrome

A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral Administration of SAR441000 as Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

SPRINT: Signature for Pain Recovery IN Teens

Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI)

PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant

Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors

Study to Evaluate the Safety and Efficacy of Pegvaliase in Adolescents (Ages 12-17) With Phenylketonuria

A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)

Effectiveness of Remote Foot Temperature Monitoring

Study of mRNA Vaccine Formulation Against COVID-19 in Healthy Adults 18 Years of Age and Older

A Study of an Investigational Flu Seasonal/SARS-CoV-2 Combination Vaccine in Adults

A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

PROmotion of COVID-19 BOOSTer VA(X)Ccination in the Emergency Department - PROBOOSTVAXED

Use of Dalfampridine in Primary Lateral Sclerosis