Clinical Trials in Ohio

Showing 3761-3780 of 17,983 trials

Comparing Hypothermic Temperatures During Hemiarch Surgery

NCT02860364

Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to either mild (32°C) or moderate (26°C) hypothermia during aortic hemiarch surgery to determine if mild hypothermia reduces the length of cardiopulmonary bypass time and other key measures of morbidity and mortality.

Thoracic Aortic Disease

Ottawa Heart Institute Research Corporation282 participantsStarted Feb 2018

Boston, Massachusetts, United States • Ridgewood, New Jersey, United States • Columbus, Ohio, United States +9 more locations

COMPLETEDPhase 1/232 miles

CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma

NCT03425279

The objective of this study is to assess the safety and efficacy of mecbotamab vedotin (BA3011) in solid tumors.

Undifferentiated Pleomorphic SarcomaMyxofibrosarcoma

BioAtla, Inc.245 participantsStarted Feb 2018

Tucson, Arizona, United States • Los Angeles, California, United States • Los Angeles, California, United States +37 more locations

Comparing Hypothermic Temperatures During Hemiarch Surgery

CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma

Find Trials by Condition in Ohio

Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission

A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations

Phase 2 Safety and Efficacy Evaluation of AL8326 in ≥2nd Line SCLC

Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

Weight Bearing After Pelvis and Acetabulum Fracture Fixation

Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

R-2487 in Patients With Rheumatoid Arthritis

Single-Sided Deafness and Asymmetric Hearing Loss

Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial

Computerized Registry of Patients With Venous Thromboembolism (RIETE)

Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

Study of Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) in Prevention of HIV in Cisgender Women in the United States (HPTN 102)

Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients

A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943

An Extension Study to Evaluate Safety and Efficacy in Participants Treated With CRN04894

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)