Clinical Trials in North Carolina

Showing 7921-7940 of 20,428 trials

Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas

NCT03783936

The initial intent of the study was to be a multi-center single-arm open-label Simon's two-stage Phase II clinical trial of first-line mFOLFOX6 + trastuzumab + avelumab in metastatic HER2-amplified gastric and esophageal adenocarcinomas. Accrual will halt after completion of Stage I (enrollment of 18 patients). This decision is not due to safety issues. Subjects currently on treatment will continue until criteria as defined in the protocol is met.

Gastric AdenocarcinomaEsophageal AdenocarcinomaMetastasis+1 more

Ashwin Somasundaram18 participantsStarted Jan 2019

Duarte, California, United States • Atlanta, Georgia, United States • Chicago, Illinois, United States +4 more locations

COMPLETEDPhase 157 miles

A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms

NCT03219268

The primary goal of this Phase 1 study is to characterize the safety and tolerability of tebotelimab and establish the maximum tolerated dose (MTD) of tebotelimab in advanced solid tumors, and tebotelimab in combination with margetuximab in HER2+ advanced solid tumors. Pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD), and the anti-tumor activity of tebotelimab will also be assessed.

Advanced Solid TumorsHematologic NeoplasmsOvarian Cancer+7 more

MacroGenics277 participantsStarted Aug 2017

Gilbert, Arizona, United States • Los Angeles, California, United States • Los Angeles, California, United States +37 more locations

Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas

A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms

Find Trials by Condition in North Carolina

Percutaneous Hepatic Perfusion in Patients With Hepatic-dominant Ocular Melanoma

Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease

Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)

A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma

Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy

AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation

A Study of RVT-1401 in Myasthenia Gravis (MG) Patients

Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma

Medibio DDA Confirmatory Performance Study

Study of the CD40 Agonistic Monoclonal Antibody APX005M

Second-line Treatment of HIV-1 With Ritonavir Boosted Atazanavir or Darunavir With an Optimized NRTI Backbone

ATR Inhibitor Elimusertib (BAY1895344) Plus Niraparib Phase 1b Study in Advanced Solid Tumors and Ovarian Cancer

A Study of [225Ac]-FPI-1966 in Participants With Advanced Solid Tumours

A Clinical Study Evaluating Nivolumab-containing Treatments in Patients With Advanced Non-small Cell Lung Cancer After Failing Previous PD-1/(L)1 Therapy and Chemotherapy

A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia

Study to Evaluate Safety & Efficacy of d-Amphetamine Transdermal System vs Placebo in Children & Adolescents With ADHD

Survival Prolongation by Rationale Innovative Genomics