Comparison of Two Methods in the Treatment of Cytomegalovirus of the Eyes in Patients With AIDS

Exclusion Criteria

• •Co-existing Condition:
• •Patients with the following symptoms or conditions are excluded:
• •PER AMENDMENT 4/25/96: Retinal detachment not scheduled for surgical repair, in all eyes meeting other eligibility criteria. (Was written as - No current retinal detachment (although old retinal detachments unrelated to HIV infection which have been repaired are permitted).
• •Corneal, lens, or vitreous opacification that precludes funduscopic exam.
• •Clinically significant pulmonary or neurologic impairment, such as intubation or coma. (Patients with a CNS mass or history of seizure disorder may enroll.)
• •Tuberculous, diabetic, or hypertensive retinopathy, or other retinal lesions that would interfere with measurements of response or progression.
• •Known hypersensitivity to the study drugs.
• •PER AMENDMENT 4/25/96:
• •Presence of CMV retinal lesions that are only in areas of the retina which cannot be photographed.
• •Concurrent Medication:
• •Excluded:
• •Immunomodulators, biologic response modifiers, interferon, or investigational agents that may influence course of CMV infection.
• •Systemic acyclovir or any nephrotoxic agent, specifically aminoglycosides, amphotericin B, and parenteral pentamidines.
• •Any concomitant therapy that would preclude use of cidofovir, foscarnet or ganciclovir.
• •Prior Medication:
• •Excluded: PER AMENDMENT 4/25/96:
• •Use of IV ganciclovir, foscarnet or cidofovir within 6 months prior to study enrollment. (Was written - Ganciclovir or foscarnet for non-CMV herpes infections within 6 months prior to study entry.)