Clinical Trials in Michigan

Showing 9261-9280 of 16,154 trials

Fc factOrs and Real-World hemophiliA Patient-ReporteD Outcomes

NCT02392156

The primary objective of the study is to evaluate the effectiveness of prophylactic treatment with recombinant Factor VIII Fc fusion protein (rFVIIIFc) and recombinant Factor IX Fc fusion protein (rFIXFc) therapy as assessed by patient treatment burden and health economic outcomes while maintaining disease control in males with hemophilia A or B.

Hemophilia AHemophilia B

Bioverativ Therapeutics Inc.3 participantsStarted Jul 2015

Los Angeles, California, United States • East Lansing, Michigan, United States

COMPLETEDPhase 383 miles

Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD

NCT02357576

Parenteral nutrition-associated cholestasis (PNAC) and liver disease (PNALD) are associated with significant morbidity and mortality in neonates and is felt to be exacerbated by soybean-based lipid emulsions. Much research is currently being directed at identifying ways to reduce this risk. Reduction of the dose of soybean-based lipid given as a component of parenteral nutrition is one possible strategy. In this study we will compare standard dosing of soybean-based lipid (up to 3/kg/day) with a minimized dose (1 g/kg/day) and evaluate for the development of cholestasis and adequate growth between the two groups. Longterm followup will include an assessment of neurodevelopmental outcomes at 12 and 24 months of age. Funding source - FDA OOPD

Cholestasis

University of Michigan22 participantsStarted May 2016

Aurora, Colorado, United States • Gainesville, Florida, United States • Ann Arbor, Michigan, United States +2 more locations

Fc factOrs and Real-World hemophiliA Patient-ReporteD Outcomes

Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD

Find Trials by Condition in Michigan

A Trial of LEE011 in Patients With Advanced Solid Tumors or Lymphoma.

Tifacogin for the Treatment of Patients With Severe Community-Acquired Pneumonia

A Phase I, Multi-center, Open Label, Drug-drug Interaction Study to Assess the Effect of Ceritinib on the Pharmacokinetics of Warfarin and Midazolam in Patients With ALK-positive Advanced Tumors

Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis

Efficacy and Safety of Patupilone in Men (≥18 Years) With Metastatic Hormone Refractory Prostate Cancer

Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months), in Renal Transplant Patients

Dose Finding Study for QAW039 in Asthma

A Pilot Study to Assess the Efficacy and Safety of LCQ908 Alone and in Combination With Fenofibrate or Lovaza® in Patients With Severe Hypertriglyceridemia

A Study to Evaluate the Efficacy and Safety of MIN-117 in Adult Patients With Major Depressive Disorder

An Investigational Immuno-Therapy Study of Experimental Medication BMS-986277 Given Alone and in Combination With Nivolumab in Epithelial Cancers

Safety and Efficacy of QAX576 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Phase I-II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 in Advanced Solid Malignancies, and Efficacy in HER2+ or ER+ Locally Advanced or Metastatic Breast Cancer Patients

Study to Evaluate the Pharmacokinetics of Firsocostat or Fenofibrate in Adults With Normal and Impaired Hepatic Function

Efficacy, Safety, and Pharmacokinetics of QAW039

Safety Study of LBH589 When Given in Combination With Lenalidomide and Dexamethasone in Adult Patients With Multiple Myeloma.

Efficacy, Safety and Pharmacokinetics of QAV680 Versus Placebo in Patients With Asthma

A Phase I-Ib/II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 Alone and in Combination With Bortezomib, With or Without Dexamethasone, in Patients With Relapsed or Refractory Multiple Myeloma.

Efficacy and Safety of BGG492 in the Treatment of Migraine