A Phase I-Ib/II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 Alone and in Combination With Bortezomib, With or Without Dexamethasone, in Patients With Relapsed or Refractory Multiple Myeloma.
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Novartis Pharmaceuticals
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients must have a diagnosis of active multiple myeloma.
Phase I and Phase II part: Patients must have received at least 2 but not more than 4 prior line of therapy and their disease has progressed during or after last therapy.
Phase Ib part: Patients must have received no more than 2 prior lines of therapy (excluding dexamethasone as single agent).
ECOG Performance Status of ≤ 2.
Patients must have acceptable neutrophil and platelet counts as well as adequate kidney and liver function.
Patients must have magnesium levels above lower limit of normal or correctable with supplements.
Patients must be willing and able to undergo bone marrow biopsy/aspirate.
Able to sign informed consent.
You may not be if
Prior treatment with any HSP90 or HDAC inhibitor for the treatment of multiple myeloma.
Patients with unresolved diarrhea ≥ CTCAE grade 2.
Patients with acute or chronic liver disease.
Patients using medications that have a relative risk of prolonging the QT interval.
Clinically significant cardiac diseases.
Patients with known disorders due to a deficiency in bilirubin glucuronidation (e.g. Gilbert's syndrome).
Pregnant or lactating women.
Fertile women of childbearing potential (WCBP) not using adequate contraception.
Male patients whose partners are WCBP, not using adequate contraception.
Patients who unwilling or unable to comply with the protocol.
Clareo Health | A Phase I-Ib/II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 Alone and in Combination With Bortezomib, With or Without Dexamethasone, in Patients With Relapsed or Refractory Multiple Myeloma.
