Clinical Trials in Maryland

Showing 17261-17280 of 23,284 trials

Metabolic Flexibility as a Biomarker of Adaptation to Diet and Exercise Challenges

NCT01987388

The objective is to develop a new metabolic flexibility biomarker, which has application in the study of changes diet and exercise on fuel management in humans. The new biomarker involves the characterization of an individual's metabolic flexibility utilizing room calorimeters rather than the current method, which is based on glucose clamp data. It is hypothesized that this new metabolic flexibility method will be a useful and noninvasive biomarker for measuring adaptation to exercise and diet challenges.

Healthy Volunteers

USDA Beltsville Human Nutrition Research Center16 participantsStarted Dec 2012

Beltsville, Maryland, United States

COMPLETEDPhase 115 miles

A Phase 1b Study to Assess the Safety and Anti-inflammatory Effects of Two Different Doses of SRT2104 in Patients With Ulcerative Colitis

NCT01453491

The purpose of this research study is to: * 1\) Test the safety and tolerability of 2 different oral doses of SRT2104 in subjects with ulcerative colitis * 2\) Determine the amount of SRT2104 measured from a single blood sample in addition to colon and/or rectal tissue samples (biopsies) * 3\) Determine whether SRT2104 has any anti-inflammatory effect on the colon and/or rectum when taken orally for 8 weeks * 4\) Determine whether SRT2104 causes any detectable changes to specific biomarkers. A biomarker is a biological marker (or substance such as a protein) that is used as an indicator of changes in a biological state that corresponds to the risk or progression of a disease.

Colitis, Ulcerative

Sirtris, a GSK Company17 participantsStarted Feb 2012

Anaheim, California, United States • Bristol, Connecticut, United States • Owensboro, Kentucky, United States +10 more locations

Metabolic Flexibility as a Biomarker of Adaptation to Diet and Exercise Challenges

A Phase 1b Study to Assess the Safety and Anti-inflammatory Effects of Two Different Doses of SRT2104 in Patients With Ulcerative Colitis

Find Trials by Condition in Maryland

Monitoring Disease Activity Using Video Capsule Endoscopy (VCE) in Crohn's Disease (CD) Subjects

A Multicenter, Open-label, Phase 1b Study of Carfilzomib, Cyclophosphamide and Dexamethasone in Newly Diagnosed Multiple Myeloma Subjects

Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection

Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations

A Prospective Study to Collect High-Quality Documentation of Bleeds, Health-Related Quality of Life (HRQoL), and Safety Outcomes in Patients With Hemophilia A Treated With Standard-of-Care Treatment

A Phase 2, Multicenter, Open-label Study of MEDI-551 in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Phase III Randomized Study of SYNSORB Pk in Children With E. Coli-Associated Hemolytic Uremic Syndrome

Bisphosphonate Treatment of Osteogenesis Imperfecta

A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy

A Bioequivalence Study of Two Oral Formulations of Topotecan in Patients With Advanced Solid Tumors

PK Study of Dapagliflozin in Pediatric Subjects With T2DM

An Open-label, Multi-center Clinical Trial of Eculizumab in Adult Patients With Atypical Hemolytic-uremic Syndrome

Phase 1b Multicenter Study of Carfilzomib With Lenalidomide and Dexamethasone in Relapsed Multiple Myeloma

A Phase II Trial of Ofatumumab in Subjects With Waldenstrom's Macroglobulinemia

Covered Metallic Stents for First-Line Treatment of Benign Bile Duct Strictures

A Long Term Safety Study of Mavrilimumab in Adult Subjects With Rheumatoid Arthritis

BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis